Porous silicon drug-eluting particles
View Patent ↗The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention comprises a biodegradable porous silicon body, a reservoir formed within the porous silicon body having at least one opening to an exterior of the body, wherein the reservoir contains a therapeutic or diagnostic agent, and an agent-permeable seal disposed over the at least one opening. The invention further provides a method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering a sustained release drug delivery particle of the invention. The invention also provides methods of fabricating a drug-eluting particle for releasing therapeutic agents.
1. A biodegradable drug-eluting particle comprising:
a porous silica body;
a reservoir formed within the porous silica body having at least one opening to an exterior of the body, wherein the reservoir has a diameter of at least about 120 μm;
a drug core within the reservoir wherein the drug core comprises a therapeutic or diagnostic agent; and
an agent-permeable seal disposed over the at least one opening.
2. The particle of claim 1 , wherein the particle has at least two openings to an exterior of the body and an agent-permeable seal disposed over the at least two openings.
3. The particle of claim 2 , wherein the particle has a plurality of openings to an exterior of the body and one or more agent-permeable seals covering each of the plurality of openings.
4. The particle of claim 1 , wherein the particle has at least one dimension less than 1 mm.
5. The particle of claim 1 , wherein the porous silica body is mesoporous.
6. The particle of claim 1 , wherein the drug core comprises 0.01 to 50 mg of the agent.
7. The particle of claim 1 , wherein the drug core comprises from 0.05 to 20 mg of the agent.
8. The particle of claim 1 , wherein the drug core comprises a therapeutic agent.
9. The particle of claim 8 , wherein the therapeutic agent is for treating or preventing an ocular condition.
10. The particle of claim 9 , wherein the therapeutic agent is fluocinolone acetonide.
11. The particle of claim 1 , wherein the drug core comprises a diagnostic agent.
12. The particle of claim 11 , wherein the diagnostic agent is for ophthalmic use.
13. The particle of claim 1 , wherein the particle is partially biodegradable in a patient.
14. A method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering the biodegradable drug-eluting particle of claim 1 to a patient and allowing the agent to elute from the particle and come in direct contact with cells or tissues of the patient.