METHODS AND COMPOSITIONS FOR REGULATING CONVERSION OF A PRODRUG TO AN ACTIVE PHARMACEUTICAL INGREDIENT
An abuse deterrent pharmaceutical composition including an abuse deterrent pharmaceutical composition including a prodrug of a pharmaceutically active ingredient and an enzyme inhibitor, wherein the enzyme inhibitor retards conversion of the prodrug to the pharmaceutically active ingredient when the composition is ingested in excess of an intended dosage.
1 . An abuse deterrent pharmaceutical composition comprising:
a. a prodrug of a pharmaceutically active ingredient; and
b. an enzyme inhibitor;
wherein the enzyme inhibitor retards conversion of the prodrug to the pharmaceutically active ingredient when the composition is ingested in excess of an intended dosage.
2 . The composition of claim 1 , wherein the prodrug comprises a pharmaceutically active ingredient modified with a promoiety.
3 . The composition of claim 2 , wherein the promoiety modifies a ketone group of the pharmaceutically active ingredient.
4 . The composition of claim 2 , wherein the promoiety modifies a hydroxyl group of the pharmaceutically active ingredient.
5 . The composition of claim 1 , wherein the pharmaceutically active ingredient comprises a drug susceptible to abuse.
6 . The composition of claim 1 , wherein the enzyme inhibitor is configured to bind with an enzyme when the composition is ingested in excess of an intended dosage.
7 . The composition of claim 6 , wherein the enzyme is selected from the group consisting of:
CYP2D6, CYP3A4, CYP2D6, CYP2C8, CYP2C19, CYP2D6, and CYP2C9.
8 . The composition of claim 6 , wherein the enzyme is a digestive enzyme.
9 . The composition of claim 1 , wherein the enzyme inhibitor is configured to protect the promoiety from being removed by an enzyme when the composition is ingested in excess of an intended dosage.
10 . The composition of claim 3 , wherein the promoiety is attached to the pharmaceutically active ingredient by an enzymatically cleavable bond.
11 . The composition of claim 10 , wherein the enzyme inhibitor is configured to protect the enzymatically cleavable bond from being cleaved by an enzyme when the composition is ingested in excess of an intended dosage.
12 . The composition of claim 9 , wherein the enzyme is selected from the group consisting of:
CYP2D6, CYP3A4, CYP2D6, CYP2C8, CYP2C19, CYP2D6, and CYP2C9.
13 . The composition of claim 9 , wherein the enzyme is a digestive enzyme.
14 . The composition of claim 1 , wherein the pharmaceutically active ingredient is an opioid.
15 . The composition of claim 1 , wherein the prodrug is an ester of the pharmaceutically active ingredient.