Compositions and methods for treating diseases of the nail

1. A method for the treatment of onychomycosis comprising topically applying to the surface of the nail of an individual suffering from onychomycosis a pharmaceutical composition comprising:

50% w/w to 70% w/w ethanol,

8% w/w to 15% w/w diisopropyl adipate,

8% w/w to 15% w/w C12-15 alkyl lactate,

10% w/w to 15% w/w cyclomethicone, and

2% w/w to 15% w/w (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)butane-2-ol;

wherein the composition is formulated as a solution; and

wherein the application of the composition is in an amount and for a time sufficient to ameliorate the symptoms of the onychomycosis.

2. The method of claim 1 , wherein the pharmaceutical composition comprises about 12% w/w diisopropyl adipate, about 10% w/w C12-15 alkyl lactate, and about 13% w/w cyclomethicone.

3. The method of claim 2 , wherein the pharmaceutical composition comprises about 10% w/w (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)butane-2-ol.

4. The method of claim 1 , wherein the pharmaceutical composition comprises about 57% w/w ethanol.

5. The method of claim 4 , wherein the pharmaceutical composition comprises about 10% w/w (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)butane-2-ol.

6. The method of claim 1 , wherein the pharmaceutical composition does not comprise a polymeric film forming compound.

7. The method of claim 2 , wherein the pharmaceutical composition does not comprise a polymeric film forming compound.

8. The method of claim 3 , wherein the pharmaceutical composition does not comprise a polymeric film forming compound.

9. The method of claim 4 , wherein the pharmaceutical composition does not comprise a polymeric film forming compound.

10. The method of claim 5 , wherein the pharmaceutical composition does not comprise a polymeric film forming compound.

11. The method of claim 1 , wherein the pharmaceutical composition is administered twice daily to the surface of the nail.

12. The method of claim 1 , wherein the pharmaceutical composition is administered once daily to the surface of the nail.

13. The method of claim 1 , wherein the pharmaceutical composition is administered one weekly to the surface of the nail.

14. A method for the treatment of onychomycosis comprising topically applying to the surface of the nail of an individual suffering from onychomycosis a pharmaceutical composition comprising:

50% w/w to 70% w/w ethanol,

about 12% w/w diisopropyl adipate,

about 10% w/w C12-15 alkyl lactate,

about 13% w/w cyclomethicone, and

about 10% w/w (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)butane-2-ol;

wherein the composition is formulated as a solution; and

wherein the application of the composition is in an amount and for a time sufficient to ameliorate the symptoms of the onychomycosis.