Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse, depression, anxiety, or a compulsive disorder
The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and X are as defined in the specification.
1. A compound of formula 2, or a pharmaceutically acceptable salt or solvate thereof,
wherein:
R is H or alkyl
R 1 is alkyl or alkenyl;
R 2 is H;
R 4 and R 5 are methyl;
R 3 is aryl or heteroaryl, either of which may be substituted or unsubstituted, and X is —CH 2 CH 2 — or —CH═CH—.
2. The compound of claim 1 , wherein R is H.
3. The compound of claim 1 , wherein R 3 is unsubstituted or substituted phenyl, or unsubstituted or substituted pyridyl.
4. The compound of claim 3 , wherein R 3 is phenyl, optionally substituted with a halogen, methyl, hydroxyl or methoxy.
5. The compound of claim 3 , wherein R 3 is pyridyl, optionally substituted with a halogen, methyl, hydroxyl or methoxy.
6. The compound of claim 1 , wherein R 1 is n-propyl.
7. The compound of claim 1 , wherein R 1 is —CH 2 CH═CH 2 .
8. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable excipient or carrier.
9. A method of treating opiate abuse, alcohol abuse, cocaine abuse, depression, anxiety, or a compulsive disorder, the method comprising administering an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, to a human in need thereof.
10. The method of claim 9 for treating opiate abuse, alcohol abuse, or cocaine abuse.
11. The method of claim 10 , wherein said treating prevents relapse of the opiate abuse, alcohol abuse, or cocaine abuse.
12. The method of claim 9 for treating depression.
13. The method of claim 9 for treating anxiety.
14. The method of claim 9 for treating a compulsive disorder.
15. A method of treating opiate abuse, alcohol abuse, cocaine abuse, depression, anxiety, or a compulsive disorder, the method comprising administering an effective amount of the composition of claim 8 , or a pharmaceutically acceptable salt or solvate thereof, to a human in need thereof.
16. The method of claim 15 for treating opiate abuse, alcohol abuse, or cocaine abuse.
17. The method of claim 16 , wherein said treating prevents relapse of the opiate abuse, alcohol abuse, or cocaine abuse.
18. The method of claim 15 for treating depression.
19. The method of claim 15 for treating anxiety.
20. The method of claim 15 for treating a compulsive disorder.