Compositions and methods for enhancing brain function using acetyl-L-carnitine, huperzine A and ginkgo biloba
A nutritional supplement composition is formulated for oral administration and enhances cognitive function. It includes huperzine A, Ginkgo biloba, and acetyl-L-carnitine. The huperzine A, acetyl-L-carnitine, and Ginkgo biloba together account for at least 80 wt % of a dosage unit of the composition. The Ginkgo biloba is about 5.0% to about 12.0%, by weight of the huperzine A, acetyl-L-carnitine and Ginkgo biloba. The Ginkgo biloba and acetyl-L-carnitine are in a ratio of y:z respectively, wherein y is between about 690 and 1,030 for Ginkgo biloba and z is between about 8,000 and 12,000 for acetyl-L-carnitine.
1. A nutritional supplement composition for enhancing cognitive function, comprising:
huperzine A;
Ginkgo biloba; and
acetyl-L-carnitine;
wherein the composition is formulated for oral administration such that huperzine A, acetyl-L-carnitine, and Ginkgo biloba together account for at least 80 wt % of a dosage unit of the composition and the Ginkgo biloba is about 5.0% to about 12.0% by weight of the huperzine A, acetyl-L-carnitine and Ginkgo biloba, and the Ginkgo biloba and acetyl-L-carnitine are in a ratio of y:z respectively, wherein y is between about 690 and 1,030 for Ginkgo biloba and z is between about 8,000 and 12,000 for acetyl-L-carnitine.
2. The nutritional supplement composition of claim 1 , wherein the huperzine A, Ginkgo biloba, and acetyl-L-carnitine are in a ratio of x:y:z, respectively, wherein x is between about 0.85 and about 1.3 for huperzine A, y is between about 690 and about 1,030 for Ginkgo biloba, and z is between about 8,000 and about 12,000 for acetyl-L-carnitine.
3. The nutritional supplement composition of claim 2 , wherein x is between about 0.95 and about 1.20 for huperzine A, y is between about 775 and about 945 for Ginkgo biloba, and z is between about 9,000 and about 11,000 for acetyl-L-carnitine.
4. The nutritional supplement composition of claim 1 , wherein acetyl-L-carnitine is present in an amount from about 1,160 mg to about 1,860 mg.
5. The nutritional supplement composition of claim 1 , wherein Ginkgo biloba is present in an amount from about 100 mg to about 160 mg.
6. The nutritional supplement composition of claim 1 , wherein huperzine A is present in an amount from about 50 mcg to about 200 mcg.
7. The nutritional supplement composition of claim 1 , wherein the composition is formulated with an enteric coating.
8. The nutritional supplement composition of claim 1 , further comprising an inactive ingredient selected from the group consisting of a carrier, a binder, an excipient, a dye, and combinations thereof.
9. The nutritional supplement composition of claim 1 , wherein huperzine A, Ginkgo biloba, and acetyl-L-carnitine together account for at least 90 wt % of a dosage unit of the composition.
10. The nutritional supplement composition of claim 1 , wherein huperzine A, Ginkgo biloba, and acetyl-L-carnitine together account for at least 95 wt % of the dosage unit of the composition.
11. The nutritional supplement composition of claim 1 , wherein the dosage unit of the composition is equal to or less than about 1,500 mg.
12. A nutritional supplement composition for enhancing cognitive function, comprising:
huperzine A;
rhodiola;
Ginkgo biloba;
acetyl-L-carnitine;
biotin; and
alpha lipoic acid;
wherein the composition is formulated for oral administration such that the huperzine A, rhodiola, Ginkgo biloba, acetyl-L-carnitine, biotin, and alpha lipoic acid together account for at least 80 wt % of a dosage unit of the composition and the Ginkgo biloba is about 3.5 percent to about 8.5 percent by weight of the huperzine A, rhodiola, Ginkgo biloba, acetyl-L-carnitine, biotin and alpha lipoic acid and the alpha lipoic acid is about 11.0 percent to about 26.0 percent by weight of the huperzine A, rhodiola, Ginkgo biloba, acetyl-L-carnitine biotin and alpha lipoic acid, and the Ginkgo biloba and acetyl-L-carnitine are in a ratio of y:z respectively, wherein y is between about 690 and 1,030 for Ginkgo biloba, and z is between about 8,000 and 12,000 for acetyl-L-carnitine.
13. The nutritional supplement composition of claim 12 , wherein acetyl-L-carnitine is present in an amount from about 1,160 mg to about 1,860 mg.
14. The nutritional supplement composition of claim 12 , wherein rhodiola is present in an amount from about 250 mg to about 350 mg.
15. The nutritional supplement composition of claim 12 , wherein huperzine A is present in an amount from about 50 mcg to about 200 mcg.
16. The nutritional supplement composition of claim 12 , wherein Ginkgo biloba is present in an amount from about 100 mg to about 160 mg.
17. The nutritional supplement composition of claim 12 , further wherein alpha lipoic acid is present in an amount from about 300 mg to about 500 mg.
18. The nutritional supplement composition of claim 12 , wherein biotin is present in an amount from about 400 mcg to about 600 mcg.
19. The nutritional supplement composition of claim 12 , wherein the dosage unit of the composition is equal or less than about 1,500 mg.
20. A nutritional supplement composition for enhancing cognitive function, comprising:
huperzine A;
Ginkgo biloba; and
acetyl-L-carnitine;
wherein the composition is formulated for oral administration such that huperzine A, acetyl-L-carnitine, and Ginkgo biloba together account for at least 80 wt % of a dosage unit of the composition and the Ginkgo biloba is about 5.0% to about 12.0% by weight of the huperzine A, acetyl-L-carnitine and Ginkgo biloba, and wherein the Ginkgo biloba is present in an amount from about 100 mg to about 160 mg, and wherein the Ginkgo biloba and acetyl-L-carnitine are in a ratio of y:z respectively, wherein y is between about 690 and 1,030 for Ginkgo biloba and z is between about 8,000 and 12,000 for acetyl-L-carnitine.
21. The nutritional supplement composition of claim 20 , wherein the huperzine A, Ginkgo biloba, and acetyl-L-carnitine are in a ratio of x:y:z, respectively, wherein x is between about 0.85 and about 1.3 for huperzine A, y is between about 690 and about 1,030 for Ginkgo biloba, and z is between about 8,000 and about 12,000 for acetyl-L-carnitine.
22. The nutritional supplement composition of claim 20 , wherein x is between about 0.95 and about 1.20 for huperzine A, y is between about 775 and about 945 for Ginkgo biloba, and z is between about 9,000 and about 11,000 for acetyl-L-carnitine.
23. The nutritional supplement composition of claim 20 , wherein the composition is formulated with an enteric coating.
24. The nutritional supplement composition of claim 20 , further comprising an inactive ingredient selected from the group consisting of a carrier, a binder, an excipient, a dye, and combinations thereof.
25. The nutritional supplement composition of claim 20 , wherein huperzine A, Ginkgo biloba, and acetyl-L-carnitine together account for at least 95 wt % of the dosage unit of the composition.
26. The nutritional supplement composition of claim 20 , wherein the dosage unit of the composition is equal to or less than about 1,600 mg.