Therapeutically active compounds and their methods of use
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
1. A method of synthesizing
comprising reacting 1-[4-chloro-6-(6-trifluoromethylpyridin-2-yl)-[1,3,5]triazin-2-ylamino]-2-methylpropan-2-ol with 2-trifluoromethylpyridin-4-ylamine in the presence of sodium tert-butoxide and Pd(dppf)Cl 2 .
2. The method of claim 1 , wherein the 1-[4-chloro-6-(6-trifluoromethylpyridin-2-yl)-[1,3,5]triazin-2-ylamino]-2-methylpropan-2-ol is synthesized by a method comprising reacting 2,4-dichloro-6-(6-trifluoromethylpyridin-2-yl)-1,3,5-triazine with 2-hydroxy-2-methyl-1-propylamine.
3. The method of claim 2 , wherein the 2,4-dichloro-6-(6-trifluoromethylpyridin-2-yl)-1,3,5-triazine is synthesized by a method comprising reacting 6-(6-trifluoromethylpyridin-2-yl)-1H-1,3,5-triazine-2,4-dione with POCl 3 and PCl 5 .
4. The method of claim 3 , wherein the 6-(6-trifluoromethylpyridin-2-yl)-1H-1,3,5-triazine-2,4-dione is synthesized by a method comprising reacting 6-trifluoromethylpyridine-2-carboxylic acid methyl ester with biuret in the presence of Na in ethanol.