Breath Analysis Apparatus and Methods of Use Thereof
We disclose a device for measuring volatile organic compounds (VOCs) in exhaled breath. The device includes a cover which may be a mask. The cover fits over a user's face as the user breathes. The cover includes one or more removably attached filters which collect VOCs. Some embodiments include reference filters which measure VOCs in the air the user inhales. Reference filter measurements may be subtracted from total VOCs collected from exhaled breath to exclude VOCs that did not originate in the user's body. The filters may be removed from the device and sent for analysis by a gas analyzer which may be a gas chromatograph. Methods of using the device are also disclosed. The device may be used to assess a user's health status, identify or quantify compounds to which a user may have been exposed, or to aid in medical diagnosis.
1 . A device for collecting volatile organic compounds for analysis from the breath of a user comprising:
a concave mask, the mask comprising:
an outer side;
an inner side;
an air permeable area; and
an air impermeable area, the air impermeable area comprising a polymer or copolymer;
a first cartridge;
wherein the first cartridge is removably attached to the mask,
wherein the first cartridge is positioned adjacent to the air permeable area of the mask,
wherein air flows from the inner side to the outer side of the mask through the first cartridge, and
wherein the first cartridge comprises:
a first one-way valve; and
a first filter;
wherein the first filter comprises a material which collects volatile organic compounds,
wherein the first filter is removably positioned within the first cartridge, and
wherein the first filter is air permeable.
2 . The device of claim 1 , wherein the first filter comprises one or more of the following: film, carbon paper, polymer, metal frit, molecular sieve, and carbon cloth.
3 . The device of claim 1 , wherein the first cartridge is attached to a first mounting fixture, wherein the first mounting fixture is attached to the outer side of the mask.
4 . The device of claim 1 , wherein the first cartridge further comprises a second one-way valve, and where in the first filter is positioned between the first one-way valve and the second one-way valve.
5 . The device of claim 7 , wherein the first and second one-way valves permit air flow from the outer side to the inner side of the mask.
6 . The device of claim 1 , wherein the mask further comprises an air port.
7 . The device of claim 1 , wherein the device is incorporated into a biomedical sensing station.
8 . The device of claim 7 , wherein the biomedical sensing station is a medical toilet.
9 . The device of claim 8 , wherein the medical toilet measures blood pressure and analyzes the content of urine and feces.
10 . The device of claim 1 further comprising:
a second cartridge;
wherein the second cartridge is removably attached to the mask,
wherein the second cartridge is positioned adjacent to the air permeable area of the mask,
wherein air flows from the outer side to the inner side of the mask through the second cartridge and
wherein the second cartridge comprises:
a third one-way valve; and
a second filter;
wherein the second filter comprises a material which collects volatile organic compounds,
wherein the second filter is removably positioned within the second cartridge, and
wherein the second filter is air permeable.
11 . The device of claim 10 , wherein the second filter comprises one or more of the following: film, carbon paper, polymer, metal frit, molecular sieve, and carbon cloth.
12 . The device of claim 10 , wherein the second cartridge is attached to a second mounting fixture, wherein the second mounting fixture is attached to the outer side of the mask.
13 . The device of claim 10 , wherein the second cartridge further comprises a fourth one-way valve, and where in the second filter is positioned between the third one-way valve and the fourth one-way valve.
14 . The device of claim 13 , wherein the third and fourth one-way valves permit air flow from the inner side to the outer side of the mask.
15 . The device of claim 10 , wherein the first filter accumulates volatile organic compounds from an air source air to be inhaled by a user and the second filter accumulates volatile organic compounds from air exhaled by a user.
16 . The device of claim 10 , wherein the mask further comprises an air port.
17 . The device of claim 10 , wherein the device is incorporated into a biomedical sensing station.
18 . The device of claim 10 , wherein the biomedical sensing station is a medical toilet.
19 . The device of claim 18 , wherein the medical toilet measures blood pressure and analyzes the content of urine and feces.
20 . The device of claim 19 , wherein the medical toilet comprises a container which houses breathable air, wherein second cartridge is connected to an air port, and wherein the air port is connected to the container.