IP Library › Granted Patent US 9,751,854
Granted Patent B2
US 9,751,854 · App. 15/347,334 · Granted Sep 5, 2017

Heteroaryls and uses thereof

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Quick Facts
Patent No.
US 9,751,854
App. No.
15/347,334
Granted
Sep 5, 2017
Kind
B2
Abstract

The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , L 1 , L 2 , m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Claims (15)

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , which is

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , which is

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 , which is

or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

6. The pharmaceutical composition of claim 5 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

7. The pharmaceutical composition of claim 5 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

8. The pharmaceutical composition of claim 5 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2021
From: MILLENNIUM PHARMACEUTICALS, INC.
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 056729/0503 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2017
From: BHARATHAN, INDU T.; BLACKBURN, CHRIS; CIAVARRI, JEFFREY P.; CHOUITAR, JOUHARA; CULLIS, COURTNEY A.; D'AMORE, NATALIE; FLEMING, PAUL E.; GIGSTAD, KENNETH M.; GIPSON, KRISTA E.; GIRARD, MARIO; HU, YONGBO; LEE, JANICE; LI, GANG; REZAEI, MANSOUREH; SINTCHAK, MICHAEL D.; SOUCY, FRANCOIS; STROUD, STEPHEN G.; VOS, TRICIA J.; WONG, TZU-TSHIN; XU, HE; XU, TIANLIN; YE, YINGCHUN
To: MILLENNIUM PHARMACEUTICALS, INC.
Reel/Frame 042496/0079 →