Methods for delivery of therapeutic materials to treat pancreatic cancer

1. A kit, comprising:

a chemotherapeutic agent; and

a catheter device including:

an inner catheter defining an inner catheter lumen configured to receive a guidewire;

a first occlusion element coupled to the inner catheter at a first axial location along the catheter device;

an outer catheter including a side wall defining an infusion aperture, the outer catheter defining a first lumen in fluid communication with the infusion aperture and a second lumen, a portion of the inner catheter being slidably disposed within the second lumen;

a second occlusion element coupled to the outer catheter at a second axial location along the catheter device, the second axial location spaced apart from the first axial location such that the infusion aperture is between the first occlusion element and the second occlusion element, the first occlusion element and the second occlusion element being configured to isolate a segment of a vessel; and

an adapter coupled to the outer catheter, the adapter including a first port and a second port, the first port in fluid communication with the first lumen through which the chemotherapeutic agent can be conveyed to the segment of the vessel isolated by the first occlusion element and the second occlusion element, the second port in fluid communication with the second lumen.

2. The kit of claim 1 , wherein:

the vessel is a splenic artery; and

the second axial location is spaced apart from the first axial location by a distance associated with the splenic artery.

3. The kit of claim 2 , wherein the distance is between 3 cm and 15 cm.

4. The kit of claim 1 , wherein the catheter device further includes a pressure sensor disposed between the first occlusion element and the second occlusion element, the pressure sensor configured to measure a fluid pressure within the segment of the vessel isolated by the first occlusion element and the second occlusion element.

5. The kit of claim 1 , wherein the catheter device includes a sealing element coupled to the outer catheter between the inner catheter and the outer catheter, the sealing element configured to prevent the chemotherapeutic agent from entering the second lumen of the outer catheter.

6. The kit of claim 1 , wherein:

the first occlusion element and the second occlusion element are each configured to be transitioned from a collapsed configuration to an expanded configuration, the first occlusion element and the second occlusion element isolating the segment of the vessel when each of the first occlusion element and the second occlusion element are in their expanded configuration;

and

the adapter includes a third port fluidically coupled to the second occlusion element, the second port configured to convey an inflation medium to the second occlusion element to transition the second occlusion element from its collapsed configuration to its expanded configuration.

7. The kit of claim 1 , wherein the catheter device includes a pressure monitoring port in line with the infusion aperture and through which an infusion pressure within the isolated segment of the vessel between the first occlusion element and the second occlusion element can be measured.

8. A kit, comprising:

a chemotherapeutic agent; and

a catheter device including:

an inner catheter including a first occlusion element, the inner catheter defining an inner catheter lumen and an opening at a distal end of the inner catheter in fluid communication with the inner catheter lumen and an environment exterior to the inner catheter and the first occlusion element;

an outer catheter including a second occlusion element and a side wall, the side wall defining an infusion aperture, the outer catheter defining a first lumen in fluid communication with the infusion aperture and a second lumen within which a first portion of the inner catheter is slidably received, the second occlusion element spaced apart from the first occlusion element by a distance such that the first occlusion element and the second occlusion element are configured to isolate a segment of a vessel; and

an adapter coupled to the outer catheter, the adapter including a first port and a second port, the first port in fluid communication with the first lumen through which the chemotherapeutic agent can be conveyed to the segment of the vessel isolated by the first occlusion element and the second occlusion element, the second port configured to receive a second portion of the inner catheter,

the catheter device configured to be coupled to a pressure sensor to monitor an infusion pressure within the segment of the vessel isolated by the first occlusion element and the second occlusion element.

9. The kit of claim 8 , wherein the first port is configured to be coupled to a pressurized delivery source containing the chemotherapeutic agent.

10. The kit of claim 9 , further comprising:

a pressure regulator configured to regulate the infusion pressure when the chemotherapeutic agent is conveyed to the segment of the vessel isolated by the first occlusion element and the second occlusion element.

11. The kit of claim 9 , further comprising:

the pressure sensor, the pressure sensor being disposed between the first occlusion element and the second occlusion element.

12. The kit of claim 8 , wherein the catheter device is configured to be manipulated to adjust the distance.

13. The kit of claim 12 , wherein the inner catheter is configured to move within the second lumen to adjust the distance.

14. The kit of claim 8 , wherein the catheter device includes a sealing element coupled between the inner catheter and the outer catheter and configured to prevent the chemotherapeutic agent from entering the second lumen of the outer catheter.