IP Library › Patent Application 15355213
Patent Application
App. No. 15/355,213

SRM METHODS IN ALZHEIMER'S DISEASE AND NEUROLOGICAL DISEASE ASSAYS

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Quick Facts
Patent No.
US None
App. No.
15/355,213
Abstract

Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays.

Claims (6)

1 . A multiplexed LC-SRM-MS assay for the measurement of a plurality of proteins in a single sample comprising:

a) generating a set of optimal peptides and corresponding transitions for each pro-tein monitored;

b) optimizing the collision energy for each transition such that interference among the transitions monitored is avoided;

c) selecting a set of transitions that have the greatest peak areas are monitored for each of the proteins, and wherein the selected transitions do not interfere with the ions in the sample;

d) monitoring the detected set of transitions for each protein in the sample, thereby measuring a plurality of proteins in the sample.

2 - 16 . (canceled)

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 5, 2017
From: KEARNEY, PAUL EDWARD; LI, XIAO-JUN; HAYWARD, CLIVE
To: INTEGRATED DIAGNOSTICS, INC.
Reel/Frame 042252/0805 →