IP Library Granted Patent US 10,016,450
Granted Patent B2
US 10,016,450 · App. 15/357,230 · Granted Jul 10, 2018

Anti-glycation methods and compositions

Inventors: Roger Blotsky (Goodyear, AZ); Krys Bojanowski (Goodyear, AZ); Ramon Figueroa (Miami, FL); Reynold Dominguez (Miami, FL)
Assignee: Core Intellectual Properties Holdings, LLC
A61K31/704A23K20/121A23L2/52A23L2/60A23L27/36A23L33/105A23L33/16A61K31/7042A61K33/00A61K33/04A61K33/06A61K33/14A61K33/16A61K33/18A61K33/20A61K33/22A61K33/24A61K33/245A61K33/26A61K33/28A61K33/30A61K33/32A61K33/34A61K33/36A61K33/38A61K33/40A61K33/42A61K33/44A61K35/08A23V2002/00
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Quick Facts
Patent No.
US 10,016,450
App. No.
15/357,230
Granted
Jul 10, 2018
Kind
B2
Abstract

The present invention comprises compositions that provide anti-glycation activity comprising a mineral extract composition or a mogroside/mineral extract composition or a mogroside composition. Such compositions are useful for methods of preventing, treating and inhibiting the effects of glycation in the body. The methods of the present invention comprise use of anti-glycation composition for the treatment and prevention of glycation related conditions including diabetes, atherosclerosis, arthritis, mental conditions and vision impairment.

Claims (40)

1. A method of increasing cellular metabolic rate, comprising, administering to at least one cell of a human or animal an effective amount of an extracted mineral element composition wherein said extracted mineral element composition is prepared by a method consisting of:

one acid treatment step, a settling step, a separating step, and a concentration step,

wherein the one acid treatment step consists of admixing a clay soil, a mixture of clay soils, or a mixture of clay soils and leonardite with water in an amount at least two times the weight of the soil and an acid to produce a water-acid-soil slurry, wherein the amount of acid is 0.25% to 7.5% of the weight of the water;

wherein the settling step consists of allowing solids from the water-acid-soil slurry to settle;

wherein the separating step consists of separating the liquid of the water-acid-soil slurry from the settled solids wherein the solids comprise substantially all of the silica and aluminum from the clay soil, mixture of clay soils, or a mixture of clay soils and leonardite;

wherein the concentrating step consists of concentrating the separated liquid to form a liquid extracted mineral element composition comprising (i) calcium, chlorine, magnesium, manganese, phosphorous, potassium, silicon, and sodium, and (ii) a lower amount of silica and aluminum than the clay soil, a mixture of clay soils, or a mixture of clay soils and leonardite; and

wherein the amount is effective in reducing at least a portion of an effect of glycation end products on cellular metabolic rate in at least one cell of a human or animal.

2. The method of claim 1 , wherein the composition further comprises a sweetener.

3. The method of claim 1 , wherein the composition further comprises a foodstuff.

4. The method of claim 1 , wherein the composition further comprises a beverage.

5. The method of claim 1 , wherein the composition further comprises a dietary supplement.

6. The method of claim 1 , wherein the composition further comprises botanicals.

7. The method of claim 1 , wherein the composition is provided in vivo to at least one cell of a human or animal.

8. The method of claim 1 , wherein the composition is provided in vitro to at least one cell of a human or animal.

9. A method of increasing cellular metabolic function, comprising, administering to at least one cell of a human or animal an effective amount of an extracted mineral element composition wherein said extracted mineral element composition is prepared by a method consisting of:

one acid treatment step, a settling step, a separating step, and a concentration step, and a drying step,

wherein the one acid treatment step consists of admixing a clay soil, a mixture of clay soils, or a mixture of clay soils and leonardite with water in an amount at least two times the weight of the soil and an acid to produce a water-acid-soil slurry, wherein the amount of acid is 0.25% to 7.5% of the weight of the water;

wherein the settling step consists of allowing solids from the water-acid-soil slurry to settle;

wherein the separating step consists of separating the liquid of the water-acid-soil slurry from the settled solids wherein the solids comprise substantially all of the silica and aluminum from the clay soil, mixture of clay soils, or a mixture of clay soils and leonardite;

wherein the concentrating step consists of concentrating the separated liquid to form a liquid extracted mineral element composition comprising (i) calcium, chlorine, magnesium, manganese, phosphorous, potassium, silicon, and sodium, and (ii) a lower amount of silica and aluminum than the clay soil, a mixture of clay soils, or a mixture of clay soils and leonardite;

wherein the drying step consists of drying the concentrated liquid to form a dry extracted mineral element composition; and

wherein the amount is effective in reducing at least a portion of an effect of glycation end products on cellular metabolic function in at least one cell of a human or animal.

10. The method of claim 9 , wherein the composition further comprises a sweetener.

11. The method of claim 9 , wherein the composition further comprises a foodstuff.

12. The method of claim 9 , wherein the composition further comprises a beverage.

13. The method of claim 9 , wherein the composition further comprises a dietary supplement.

14. The method of claim 9 , wherein the composition further comprises botanicals.

15. The method of claim 9 , wherein the composition is provided in vivo to at least one cell of a human or animal.

16. The method of claim 9 , wherein the composition is provided in vitro to at least one cell of a human or animal.

17. A method of enhancing mitochrondrial function, comprising, administering to at least one cell of a human or animal an effective amount of an extracted mineral element composition wherein said extracted mineral element composition is prepared by a method consisting of:

one acid treatment step, a settling step, a separating step, and a concentration step, and a drying step,

wherein the one acid treatment step consists of admixing a clay soil, a mixture of clay soils, or a mixture of clay soils and leonardite with water in an amount at least two times the weight of the soil and an acid to produce a water-acid-soil slurry, wherein the amount of acid is 0.25% to 7.5% of the weight of the water;

wherein the settling step consists of allowing solids from the water-acid-soil slurry to settle;

wherein the separating step consists of separating the liquid of the water-acid-soil slurry from the settled solids wherein the solids comprise substantially all of the silica and aluminum from the clay soil, mixture of clay soils, or a mixture of clay soils and leonardite;

wherein the concentrating step consists of concentrating the separated liquid to form a liquid extracted mineral element composition comprising (i) calcium, chlorine, magnesium, manganese, phosphorous, potassium, silicon, and sodium, and (ii) a lower amount of silica and aluminum than the clay soil, a mixture of clay soils, or a mixture of clay soils and leonardite;

wherein the drying step consists of drying the concentrated liquid to form a dry extracted mineral element composition; and

wherein the amount is effective in reducing at least a portion of an effect of glycation end products on mitochondrial function in at least one cell of a human or animal.

18. The method of claim 17 , wherein the composition further comprises one or more of a sweetener, a foodstuff, a beverage, a dietary supplement, or a botanical.

19. The method of claim 17 , wherein the composition is provided in vivo to at least one cell of a human or animal.

20. The method of claim 17 , wherein the composition is provided in vitro to at least one cell of a human or animal.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 3, 2017
From: BLOTSKY, ROGER; BOJANOWSKI, KRYS; FIGUEROA, RAMON; DOMINGUEZ, REYNOLD
To: CORE INTELLECTUAL PROPERTIES HOLDINGS, LLC
Reel/Frame 042390/0001 →
Continuity (6)
Continuation 14806461 · Jul 22, 2015
Continuation 14553420 · Nov 25, 2014
Continuation 12249798 · Oct 10, 2008
Provisional Application 61079826 · Jul 11, 2008
Provisional Application 60998316 · Oct 10, 2007
Related Publication 20170136050A1 · May 18, 2017
Cited By (1)
US 12,202,777