Method for preparing functionalized polymers from polymer alcohols
View Patent ↗The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.
1. A composition comprising a maleimidyl-functionalized polymer having a structure:
wherein:
n is an integer from 2 to 3,000;
R 4 is selected from the group consisting of H, lower alkyl and benzyl; and
n′ is an integer from 3 to 10;
wherein said composition contains less than 0.3 weight percent of a difunctional polyethylene glycol polymer.
2. The composition of claim 1 , wherein n is an integer from 10 to 2,000.
3. The composition of claim 1 , wherein R 4 is straight chain lower alkyl.
4. The composition of claim 1 , wherein R 4 is methyl or benzyl.
5. The composition of claim 1 , wherein n′ is 3.
6. The composition of claim 1 , wherein R 4 is methyl.
7. The composition of claim 1 , wherein n is an integer from 100 to 1000.
8. The composition of claim 1 , wherein R 4 is H.