GROOVED DRUG-ELUTING MEDICAL DEVICES AND METHOD OF MAKING SAME
The invention relates to methods and apparatus for manufacturing implantable medical devices, such as intravascular stents, wherein the medical device has a surface treated to promote the migration of endothelial cells onto the surface of the medical device. In particular, the surface of the medical device has at least one groove formed therein, the at least one groove may have a drug-eluting polymer disposed therein or a drug-eluting polymer coating may be provided on the surface of the medical device and grooves formed in the drug eluting polymer coating.
1 . A method of manufacturing an implantable medical device, comprising the steps of: providing an implantable medical device having a first surface and a second surface, and forming a plurality of grooves separated by land areas in at least one of the first surface or the second surface, and either i) at least partially filling at least one groove with a polymer or ii) disposing polymer on land areas the implantable medical device.
2 . The method of claim 1 , further comprising the step of exposing the land areas of the implantable medical device while leaving the at least one groove at least partially filed with the polymer.
3 . The method of claim 1 , further comprising the step of passivating exposed metal of the implantable medical device.
4 . The method of claim 1 , further comprising the step of disposing polymer on the implantable medical device and forming the plurality of grooves through the polymer and into at least one of the first surface or second surface of the implantable medical device.
5 . The method of claim 1 , further comprising the steps of disposing polymer on at least one of the first surface or the second surface of the implantable medical device and into the plurality of grooves therein, removing a portion of the polymer such that the land areas are exposed and the polymer resides only in the plurality of grooves.