IP Library › Granted Patent US 10,383,867
Granted Patent B2
US 10,383,867 · App. 15/361,482 · Granted Aug 20, 2019

Quinoline derivatives and their use for treating endoplasmic reticulum stress-related diseases and disorders

Inventor: Russell Dahl (Saint John, IN)
A61K31/4709A61K31/47C07D215/12C07D215/14
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Quick Facts
Patent No.
US 10,383,867
App. No.
15/361,482
Granted
Aug 20, 2019
Kind
B2
Abstract

Provided herein are quinolines, e.g., a compound of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase.

Claims (2)

1. A pharmaceutical composition wherein the compound is:

or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2021
From: DAHL, RUSSELL, DR
To: NEURODON CORPORATION
Reel/Frame 055251/0757 →
Continuity (2)
Provisional Application 62260512 · Nov 28, 2015
Related Publication 20170151225A1 · Jun 1, 2017