Quinoline containing compounds and their use for treating endoplasmic reticulum stress-related diseases
View Patent ↗Provided herein are quinoline, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase.
1. A method for treating or ameliorating one or more symptoms of type 2 diabetes in a subject in need thereof, comprising administering to the subject an effective amount of a compound, wherein the compound is selected from the group consisting of:
or an isotope variant thereof, or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
2. The method of claim 1 , wherein the method comprises administering to the subject a second therapeutic agent, in combination or alternation.
3. The method of claim 1 , wherein the subject is a human.