Zirconium phosphate recharging customization
View Patent ↗The invention relates to devices, systems, and methods for recharging zirconium phosphate in a reusable zirconium phosphate sorbent module. The devices, systems, and methods provide for customization of the zirconium phosphate effluent pH based on the needs of the user and system. The devices systems and methods also provide for calculation of the volumes of recharge solution needed for fully recharging the zirconium phosphate modules.
1. A method, comprising the steps of:
determining a desired initial therapy zirconium phosphate effluent pH based on one or more patient parameters; and
recharging zirconium phosphate in a zirconium phosphate module by pumping one or more recharge solutions through the zirconium phosphate module; the one or more recharge solutions comprising an acid solution, a base solution, a buffer solution, a salt solution, water, or combinations thereof;
wherein the one or more recharge solutions have an acid concentration, a base concentration, a buffer concentration, and a salt concentration to result in the desired initial therapy zirconium phosphate effluent pH.
2. The method of claim 1 , wherein the step of pumping the one or more recharge solutions through the zirconium phosphate module comprises pumping multiple recharge solutions through the zirconium phosphate module in a sequential order.
3. The method of claim 2 , wherein the sequential order comprises a first recharge solution containing an acid or buffer, and a second recharge solution containing a sodium salt; or a first recharge solution containing a sodium salt and a second recharge solution containing an acid or buffer.
4. The method of claim 3 , wherein the buffer contains acetic acid and sodium acetate.
5. The method of claim 1 , wherein the desired initial therapy zirconium phosphate effluent pH is between 4.0 and 6.9.
6. The method of claim 1 , wherein a single recharge solution is pumped through the zirconium phosphate module.
7. The method of claim 6 , wherein the single recharge solution is a solution of acetic acid, sodium acetate, and sodium chloride.
8. The method of claim 6 , wherein the single recharge solution has a pH of between 4.2 and 5.0.
9. The method of claim 1 , further comprising the step of determining an amount of cations removed by the zirconium phosphate module in a dialysis session prior to the step of pumping one or more recharge solutions through the zirconium phosphate module.
10. The method of claim 9 , wherein a volume of recharge solution used is based, at least in part, on the amount of cations removed by the zirconium phosphate module.
11. The method of claim 9 , wherein the one or more recharge solutions contains sodium ions in an amount of between 5 and 15 times greater than the amount of cations removed by the zirconium phosphate module.
12. The method of claim 1 , further comprising the step of heating the one or more recharge solutions to a specified temperature prior to pumping the one or more recharge solutions through the zirconium phosphate module.
13. The method of claim 12 , wherein the acid concentration, the base concentration, the buffer concentration, and the salt concentration are set based at least in part on the specified temperature.
14. A recharger comprising:
a receiving compartment comprising a zirconium phosphate module inlet and a zirconium phosphate module outlet;
one or more recharge solution sources, wherein the one or more recharge solution sources are selected from the group consisting of an acid source, a base source, a salt source, a water source, and combinations thereof;
a recharging flow path fluidly connected to the one or more recharge solution sources and the zirconium phosphate module inlet, and comprising at least one pump;
a control system determining a desired initial therapy zirconium phosphate effluent pH, and determining a concentration of an acid, a base, a buffer, a salt, or combinations thereof to result in the desired initial therapy zirconium phosphate effluent pH; and
the control system controlling an amount of each recharge solution pumped through the recharging flow path.
15. The recharger of claim 14 , further comprising one or more valves fluidly connected to the one or more recharge solution sources and the recharging flow path.
16. The recharger of claim 14 , further comprising a heater and temperature sensor in the recharging flow path.
17. The recharger of claim 15 , the control system determining a volume of acid, base, buffer, and salt for recharging a zirconium phosphate module based at least in part on a temperature of one or more recharge solutions.
18. The recharger of claim 14 , the control system determining a volume of the acid, the base, the buffer, and the salt for recharging a zirconium phosphate module based at least in part on an amount of cations removed by the zirconium phosphate module during a dialysis session.
19. The recharger of claim 14 , wherein the one or more recharge solution sources comprise at least two recharge solution sources.
20. The recharger of claim 18 , further comprising a static mixer in the recharging flow path for mixing of the acid, base, buffer, or salt.