Combination therapy of a type II anti-CD20 antibody with a selective BCL-2 inhibitor

1. A method for the treatment of chronic lymphocytic leukemia in a human patient suffering from relapsed or refractory or previously untreated chronic lymphocytic leukemia, said method comprising

co-administering to the patient an effective amount of a compound, which is 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenylsulfonyl)benzamide, and obinutuzumab, in multiple dosing cycles, wherein

i) each dosing cycle of the multiple dosing cycles is 28 days;

ii) the obinutuzumab is administered once a week for two or more weeks of the first dosing cycle and is administered once per dosing cycle after the first dosing cycle of the multiple dosing cycles;

iii) the compound is administered to the human in daily doses beginning in the first dosing cycle; and

iv) the amount of the compound in the daily doses increases from a first amount administered in the first dosing cycle to a second amount administered to the human in dosing cycles after the first dosing cycle; followed by

administering to the patient daily doses of the compound alone in the absence of the obinutuzumab.

2. The method of claim 1 , wherein the first dose of the obinutuzumab administered to the human is administered as a split dose on day 1 and day 2 of the first dosing cycle.

3. The method of claim 2 , wherein the compound is administered to the human in daily doses beginning in the first dosing cycle after the first administration of the obinutuzumab.

4. The method of claim 3 , wherein the first amount of the compound administered to the human is between 10 mg to 80 mg per dose and the second amount is between 190 mg to 400 mg per dose.

5. The method of claim 4 , wherein the effective amount of the obinutuzumab is from 500 mg to 3000 mg.

6. The method of claim 5 , wherein both the obinutuzumab and the compound are co-administered to the human for 6 cycles of the multiple dosing cycles.

7. The method of claim 4 , wherein the second amount of the compound administered to the human is 400 mg.

8. The method of claim 7 , wherein the effective amount of the obinutuzumab is 1000 mg.

9. The method of claim 8 , wherein both the obinutuzumab and the compound are co-administered to the human for 6 cycles of the multiple dosing cycles.

10. The method of claim 1 , wherein the chronic lymphocytic leukemia is a CD20-expressing chronic lymphocytic leukemia.