IP Library › Patent Application 15374329
Patent Application
App. No. 15/374,329

SUBSTITUTED TETRACYCLINE COMPOUNDS

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Quick Facts
Patent No.
US None
App. No.
15/374,329
Abstract

The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.

Claims (15)

1 - 49 . (canceled)

50 . A method for ameliorating a tetracycline responsive state in a subject in need thereof, the method comprising administering to said subject a tetracycline compound of the following structural formula:

or a pharmaceutically acceptable salt thereof, such that said tetracycline responsive state in said subject is ameliorated.

51 . The method of claim 50 , wherein said tetracycline responsive state is an inflammatory disorder.

52 . The method of claim 51 , wherein said tetracycline responsive state is an inflammatory condition of the skin.

53 . The method of claim 51 , wherein said tetracycline responsive state is an inflammatory disorder caused by trauma.

54 . The method of claim 51 , wherein said tetracycline responsive state is an inflammatory disorder caused by radiation.

55 . The method of claim 50 , wherein said subject is a human.

56 . A method for ameliorating a tetracycline responsive state in a subject in need thereof, the method comprising administering to said subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a tetracycline compound of the following structural formula:

or a pharmaceutically acceptable salt thereof, such that said tetracycline responsive state in said subject is ameliorated.

57 . The method of claim 56 , wherein said tetracycline responsive state is an inflammatory disorder.

58 . The method of claim 57 , wherein said tetracycline responsive state is an inflammatory condition of the skin.

59 . The method of claim 57 , wherein said tetracycline responsive state is an inflammatory disorder caused by trauma.

60 . The method of claim 57 , wherein said tetracycline responsive state is an inflammatory disorder caused by radiation.

61 . The method of claim 56 , wherein said subject is a human.