Lubricious coatings with surface salt groups
View Patent ↗Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.
1. A method of making a medical device comprising:
obtaining a medical device comprising a base coat layer disposed over a substrate;
coating the base coat layer with a polymeric layer to dispose the polymeric layer over the base coat layer, the polymeric layer comprising an exterior surface with reactive groups disposed on the exterior surface; and
applying a solution to the exterior surface, the solution comprising an acid or a base, wherein the acid or base in the solution reacts with the reactive groups to form salt groups.
2. The method of claim 1 , further comprising rinsing the solution off of the exterior surface.
3. The method of claim 1 , the reactive groups comprising at least one selected from the group of a carboxylic acid and an amine.
4. The method of claim 1 , the reactive groups comprising acid groups.
5. The method of claim 1 , the reactive groups comprising carboxylic acids.
6. The method of claim 1 , the salt groups comprising carboxylate salts.
7. The method of claim 1 , wherein the density of salt groups is higher on the exterior surface of the polymeric layer than in the middle of the polymeric layer.
8. The method of claim 1 , the salt groups comprising a cation selected from the group consisting of sodium, potassium, lithium, calcium, zinc and ammonium.
9. The method of claim 1 , wherein the base coat layer comprises a polymer derivatized with at least one cross-linking agent.
10. The method of claim 9 , wherein the polymer derivatized with at least one cross-linking agent comprises a vinyl pyrrolidone polymer and a first cross-linking agent, the first cross-linking agent having a formula Photo 1 -LG-Photo 2 , wherein Photo 1 and Photo 2 , independently represent at least one photoreactive group and LG represents a linking group comprising at least one silicon or at least one phosphorus atom;
wherein there is a covalent linkage between the at least one photoreactive group and the linking group, and
wherein the covalent linkage between the at least one photoreactive group and the linking group is interrupted by at least one heteroatom.
11. The method of claim 1 , further comprising sterilizing the medical device.