Batch authoring tool and bioreactor control system
A bioreactor control system comprises a batch server for controlling a bioreactor system in response to a recipe, a batch software system for generating a control sequence for the bioreactor system via the batch server for implementing the recipe, and a recipe conversion system that inputs the recipe into the batch software system. Preferably, the recipe conversion system reads a word processor file containing the recipe and interprets styles applied to text in the word processor file as indicating equipment and phases of the recipe to the recipe conversion system. Generally, the bioreactor system includes one or more bioreactors and additional hardware to perform the upstream and downstream processing. The document properties of the word processor file containing the recipe are applied as header information for the recipe input into the batch software system. This system solves a problem associated with traditional batching software systems, in which the authoring of recipes on the systems can be relatively arcane. Here, the recipe can be authored on a common word processor.
1. A bioreactor control system for controlling a bioreactor system that includes a bioreactor connected to at least one of: a buffer and media preparation module, and a module for preparation of an inoculum, the bioreactor control system comprising:
a batch server that controls the bioreactor system based at least in part on a recipe;
a recipe conversion system that includes at least one processor adapted to:
read in a word processor file having a plurality of paragraphs that include instructions defining the recipe, at least one of the paragraphs having one or more applied styles;
parse the word processor file by iterating through the plurality of paragraphs and identifying the one or more applied styles;
generate the recipe based at least in part on the instructions and the identified one or more applied styles; and
execute the recipe via a piece of equipment specified by the one or more applied styles.
2. The bioreactor control system of claim 1 , wherein document properties of the word processor file are applied as header information for the recipe.
3. The bioreactor control system of claim 1 , wherein the recipe conversion system is configured to read an XML file defining the recipe.
4. The bioreactor control system of claim 1 , wherein the batch server includes a batch software system that generates a control sequence based at least in part on the recipe, and the control sequence adapts the batch server to control the bioreactor system.
5. The bioreactor control system of claim 4 , wherein the batch software system is InBatch batching software.
6. The bioreactor control system of claim 4 , wherein the batch software system is configured to download the recipe to the batch server.
7. The bioreactor control system of claim 1 , wherein the bioreactor is further connected to at least one of: a harvest/clarification module, a chromatography module, and an ultrafiltration/diafiltration (UF/DF) module.
8. A method for controlling a bioreactor system that includes a bioreactor connected to at least one of: a buffer and media preparation module, and a module for preparation of an inoculum, the method comprising:
reading in at a recipe conversion system a word processor file having a plurality of paragraphs that include instructions defining a recipe, at least one of the paragraphs having one or more applied styles;
parsing the word processor file via the recipe conversion system by iterating through the plurality of paragraphs and identifying the one or more applied styles;
generating the recipe via the recipe conversion system based at least in part on the instructions and the identified one or more applied styles; and
executing the recipe via a batch server with a piece of equipment specified by the one or more applied styles.
9. The method of claim 8 , wherein document properties of the word processor file are applied as header information for the recipe.
10. The method of claim 8 , wherein reading in at a recipe conversion system a word processor file comprises:
reading an XML file defining the recipe.
11. The method of claim 8 further comprising:
generating via a batch software system of the batch server a control sequence based at least in part on the recipe; and
wherein executing the recipe via a batch server with a piece of equipment specified by the one or more applied styles comprises:
adapting the batch server via the control sequence.
12. The method of claim 11 , wherein the batch software system is InBatch batching software.
13. The method of claim 11 further comprising:
downloading via the batch software system the recipe to the batch server.
14. The method of claim 11 , wherein the bioreactor is further connected to at least one of: a harvest/clarification module, a chromatography module, and an ultrafiltration/diafiltration (UF/DF) module.
15. A non-transitory computer readable medium storing instructions that adapt a processor to:
read in a word processor file having a plurality of paragraphs that include instructions defining a recipe, at least one of the paragraphs having one or more applied styles;
parse the word processor file by iterating through the plurality of paragraphs and identifying the one or more applied styles;
generate the recipe based at least in part on the instructions and the identified one or more applied styles; and
execute the recipe via a batch server on a piece of equipment of a bioreactor system specified by the one or more applied styles; and wherein the recipe is for a batch server that controls a bioreactor system based at least in part on the recipe, the bioreactor system including a bioreactor connected to at least one of: a buffer and media preparation module, and a module for preparation of an inoculum.
16. The non-transitory computer readable medium of claim 15 , wherein document properties of the word processor file are applied as header information for the recipe.
17. The non-transitory computer readable medium of claim 15 , wherein the at least one processor is adapted to read an XML file defining the recipe.
18. The non-transitory computer readable medium of claim 15 , wherein the batch server includes a batch software system that generates a control sequence based at least in part on the recipe, and the control sequence adapts the batch server to control the bioreactor system.
19. The non-transitory computer readable medium of claim 18 , wherein the batch software system is InBatch batching software.
20. The non-transitory computer readable medium of claim 18 , wherein the batch software system is configured to download the recipe to the batch server.