Substituted indol-5-ol derivatives and their therapeutic applications
The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
1. A method of treating cancer in a mammal, wherein the cancer is selected from the group consisting of Chronic Myelogenous Leukemia (CIVIL), Acute Myelogenous Leukemia (AML) and thyroid, endometrial, gastric, breast and pancreatic carcinoma, and wherein the method comprises administering to the mammal a therapeutically effective amount of a composition comprising NTW-3475, wherein NTW-3475 is the compound having the structure:
2. The method of claim 1 , wherein NTW-3475 is administered with other active agents.
3. The method of claim 1 , wherein NTW-3475 is administered with a carrier.
4. The method of claim 1 wherein the cancer is pancreatic carcinoma.
5. The method of claim 1 , wherein the administration of the composition results in reduced signal transduction by the pERK pathway.
6. The method of claim 1 , wherein the administration of the composition results in reduced signal transduction by the pERK pathway.
7. The method of claim 1 , wherein the mammal is human.
8. A method for reducing signal transduction by the pERK pathway in cells comprising contacting the cells with NTW-3475, wherein the cells are MiaPaCa-2 cells or BxPC3 cells, and wherein NTW-3475 is the compound having the structure:
9. The method of claim 8 , wherein the cells are in vivo.
10. The method of claim 8 , wherein the cells are human.
11. The method of claim 1 , wherein the cancer is CML.
12. The method of claim 1 , wherein the cancer is AML.
13. The method of claim 1 , wherein the cancer is thyroid carcinoma.
14. The method of claim 1 , wherein the cancer is endometrial carcinoma.
15. The method of claim 1 , wherein the cancer is gastric carcinoma.
16. The method of claim 1 , wherein the cancer is breast carcinoma.