IP Library › Granted Patent US 10,406,207
Granted Patent B2
US 10,406,207 · App. 15/381,993 · Granted Sep 10, 2019

Peptide conjugates of GLP-1 receptor agonists and gastrin and their use

Inventors: Trine Skovlund Ryge Neerup (Frederikssund, DK); Torben Østerlund (Lund, SE); Jakob Lind Tolborg (Herlev, DK); Keld Fosgerau (Rødovre, DK); Ulrika Martensson (Lund, SE); Marianne Brorson (Søborg, DK); Kamilla Rolsted (Slagelse, DK)
Assignee: Zealand Pharma A/S
A61K38/22A61K38/2207A61K38/26A61K45/06A61K47/60C07K14/463C07K14/575C07K14/57563C07K14/595C07K14/605A61K38/00
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Quick Facts
Patent No.
US 10,406,207
App. No.
15/381,993
Granted
Sep 10, 2019
Kind
B2
Abstract

The present invention relates, inter alia, to certain peptide conjugates, and to the use of the conjugates in the treatment of a variety of diseases or disorders, including diabetes (type 1 and/or type 2) and diabetes related diseases or disorders.

Claims (22)

1. A peptide conjugate or pharmaceutically acceptable salt thereof, wherein the peptide conjugate has the sequence:

Exendin-4(1-39)-Peg3-Peg3-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 1)

Exendin-4(1-39)-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 2)

Exendin-4(1-39)-K-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 3)

Exendin-4(1-39)-AAA-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 4)

Exendin-4(1-39)-SKK-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 5)

Exendin-4(1-39)-Peg3-SKK-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 6)

Exendin-4(1-39)-8Aoc-SKK-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 7)

Exendin-4(1-39)-DBF-SKK-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 8)

Exendin-4(1-39)-8Aoc-8Aoc-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 9)

Exendin-4(1-28-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 19)

Exendin-4(1-28)-K-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 20)

Exendin-4(1-28)-AAA-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 21)

Exendin-4(1-28)-SKK-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 22)

Exendin-4(1-28)-Peg3-SKK-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 23)

Exendin-4(1-28)-Peg3-Peg3-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 24)

Exendin-4(1-28)-8Aoc-SKK-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 25)

Exendin-4(1-28)-DBF-SKK-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 26)

Exendin-4(1-28)-8Aoc-8Aoc-[Gln1,Leu15]Gastrin17, (SEQ ID NO: 27).

2. A pharmaceutical composition comprising a peptide conjugate, or pharmaceutically acceptable salt thereof, according to claim 1 , in combination with one or more peptide conjugates or pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier, excipient or vehicle.

3. A device comprising at least one peptide conjugate, or pharmaceutically acceptable salt thereof, according to claim 1 , for delivery of the peptide conjugate to a subject.

4. A kit comprising at least one peptide conjugate, or pharmaceutically acceptable salt thereof, according to claim 1 , further comprising packaging or instructions for use.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded May 17, 2023
From: ZOOLANDER SA LLC
To: ZEALAND PHARMA A/S
Reel/Frame 063672/0342 →
RELEASE OF SECURITY INTEREST Recorded May 11, 2023
From: ZOOLANDER SA LLC
To: ZEALAND PHARMA A/S
Reel/Frame 063624/0547 →
PATENT SECURITY AGREEMENT Recorded Dec 27, 2021
From: ZEALAND PHARMA A/S
To: ZOOLANDER SA LLC
Reel/Frame 058593/0261 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 24, 2017
From: NEERUP, TRINE SKOVLUND RYGE; ØSTERLUND, TORBEN; TOLBORG, JAKOB LIND; FOSGERAU, KELD; MARTENSSON, ULRIKA; BRORSON, MARIANNE; ROLSTED, KAMILLA
To: ZEALAND PHARMA A/S
Reel/Frame 041367/0094 →
Priority Claims (3)
DK 2010 00379 · Apr 27, 2010 · national
DK 2010 00941 · Oct 15, 2010 · national
DK 2011 00149 · Mar 4, 2011 · national
Continuity (5)
Continuation 14735738 · Jun 10, 2015
Continuation 13642349
Provisional Application 61470170 · Mar 31, 2011
Provisional Application 61395119 · May 7, 2010
Related Publication 20170281709A1 · Oct 5, 2017