Methods and systems for directed tissue ablation
Methods of ablating endometrial tissue are disclosed. The methods include providing an ablation device that has a catheter with a hollow shaft through which an ablative agent can travel, a first positioning element, and a second positioning element positioned on the catheter distal to the first positioning element. The second positioning element is a disc shaped wire mesh and has a diameter in a range of 0.1 mm to 10 cm.
1. A vapor ablation system configured to ablate tissue in a an upper gastrointestinal (GI) tract of a patient, comprising:
a container with fluid;
a pump configured to pump the fluid from the container;
a catheter, wherein the catheter comprises:
an elongate catheter body having a lumen, a proximal end, and a distal end;
a heating component positioned within the catheter body and in fluid communication with the container, wherein the heating component is configured to apply energy to the fluid to convert the fluid to a vapor ablative agent;
at least one delivery port at the distal end of the catheter body, wherein the at least one delivery port is configured to allow the vapor ablative agent to exit the catheter body to ablate the tissue; and
an expandable positioning element attached to a distal end of the catheter body, wherein the at least one delivery port is positioned at an entrance to the expandable positioning element and not positioned on the expandable positioning element, wherein, when the expandable positioning element is expanded, the expandable positioning element is defined by an internal volume and configured to encircle the at least one delivery port and the tissue to be ablated to thereby direct-the vapor ablative agent from the at least one delivery port, through the internal volume, to the tissue to be ablated such that the vapor ablative agent exits the at least one delivery port and ablate the tissue without contacting the expandable positioning element, wherein the at least one expandable positioning element is configured to position the catheter at a fixed distance from the tissue to be ablated, wherein the expandable positioning element is defined by a conical shaped wire mesh structure that is at least partially covered by a membrane and that defines a periphery of the internal volume.
2. The vapor ablation system of claim 1 , further comprising a thermally insulated handle attached to the catheter body.
3. The vapor ablation system of claim 1 , further comprising a thermally insulating material covering the catheter body.
4. The vapor ablation system of claim 1 , wherein the heating component comprises a chamber and wherein the chamber further comprises a plurality of channels that provide a contact surface area of the fluid with the chamber.
5. The vapor ablation system of claim 4 , wherein the plurality of channels comprises metal.
6. The vapor ablation system of claim 4 , wherein the chamber is configured to apply the energy to the fluid using resistive heating.
7. The vapor ablation system of claim 1 , wherein the at least one expandable positioning element is separated from the at least one delivery port by a distance of 1 mm to 10 cm.
8. The vapor ablation system of claim 1 , further comprising a controller in operable communication with the pump and the heating component, wherein the controller is programmed to determine an amount of the fluid needed to ablate the tissue.
9. The vapor ablation system of claim 1 , further comprising a controller in operable communication with the pump and the heating component, wherein the controller is programmed to limit an amount of the vapor ablative agent delivered through the at least one delivery port such that a pressure within the GI tract of the patient does not exceed 5 atm.
10. The vapor ablation system of claim 1 , further comprising a controller in operable communication with the pump and the heating component, wherein the controller is programmed to limit a maximum dose of the vapor ablative agent based on a type of disorder being treated.
11. The vapor ablation system of claim 10 , wherein the disorder is at least one of Barrett's esophagus, dysplasia, tumors, lesions, vascular GI disorders, or polyps.
12. The vapor ablation system of claim 1 , further comprising a first filter disposed between, and in fluid communication with, the container and the catheter.
13. The vapor ablation system of claim 1 , further comprising a controller in operable communication with the pump and the heating component, wherein the controller is programmed to determine an amount of the fluid needed to ablate the tissue as a function of an amount of thermal energy required to ablate the tissue.
14. The vapor ablation system of claim 1 , further comprising a controller in operable communication with the pump and the heating component, wherein the controller is programmed to adjust a flow rate of the fluid supplied to the catheter.
15. The vapor ablation system of claim 1 , wherein the pump is a syringe pump.
16. The vapor ablation system of claim 1 , wherein the syringe pump has a volume of at least 10 ml.
17. The vapor ablation system of claim 1 , wherein the catheter is disposable and configured for a single use.
18. A vapor ablation system configured to ablate tissue in a an upper gastrointestinal (GI) tract of a patient, comprising:
a container with fluid;
a pump configured to pump the fluid from the container;
a heating chamber in fluid communication with the container, wherein the heating chamber is configured to apply energy to the fluid to convert the fluid to a vapor ablative agent;
a catheter in fluid communication with the heating chamber, wherein the catheter comprises:
a hollow shaft through which the vapor ablative agent can travel;
at least one delivery port at the distal end of the catheter body, wherein the at least one delivery port is configured to allow the vapor ablative agent to exit the catheter body to ablate the tissue; and
an expandable positioning element attached to a distal end of the catheter body and configured to be placed over the tissue and direct the vapor ablative agent from the at least one delivery port, wherein the at least one expandable positioning element is configured to position the catheter at a fixed distance from the tissue to be ablated, wherein the expandable positioning element is defined by a wire mesh structure that is at least partially covered by a membrane, and wherein the at least one delivery port is not positioned on the expandable positioning element; and
a controller programmed to limit an amount of the vapor ablative agent delivered through the at least one delivery port such that a pressure within the GI tract of the patient does not exceed 5 atm.
19. The vapor ablation system of claim 18 , wherein the wire mesh structure is conical shaped.
20. The vapor ablation system of claim 18 , further comprising a thermally insulated handle attached to the catheter body.
21. The vapor ablation system of claim 18 , further comprising a thermally insulating material covering the catheter body.
22. The vapor ablation system of claim 18 , wherein the heating chamber comprises a plurality of channels that provide a contact surface area of the fluid with the heating chamber.
23. The vapor ablation system of claim 22 , wherein the plurality of channels comprises metal.
24. The vapor ablation system of claim 18 , wherein the heating chamber is configured to apply the energy to the fluid using resistive heating.
25. The vapor ablation system of claim 18 , wherein the at least one expandable positioning element is separated from the at least one delivery port by a distance of 1 mm to 10 cm.
26. The vapor ablation system of claim 18 , wherein the controller is configured to treat a type of disorder comprising at least one of Barrett's esophagus, dysplasia, tumors, lesions, vascular GI disorders, or polyps.
27. The vapor ablation system of claim 18 , further comprising a first filter disposed between, and in fluid communication with, the container and the catheter.
28. The vapor ablation system of claim 18 , wherein the controller is programmed to determine an amount of the fluid needed to ablate the tissue as a function of an amount of thermal energy required to ablate the tissue.
29. The vapor ablation system of claim 18 , wherein the controller is programmed to adjust a flow rate of the fluid supplied to the catheter.
30. The vapor ablation system of claim 18 , wherein the pump is a syringe pump.
31. The vapor ablation system of claim 18 , wherein the syringe pump has a volume of at least 10 ml.