Cardiovascular prostheses
Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.
1. A cardiovascular prosthesis consisting of:
a sheet member consisting of an antibiotic augmented ECM-mimicking composition, said antibiotic augmented ECM-mimicking composition consisting of poly(glycerol sebacate) (PGS), vancomycin and gentamicin,
said sheet member, when disposed proximate damaged biological tissue, being adapted to induce anti-microbial and anti-biofilm activity and, thereby, enhanced inflammation modulation.
2. A cardiovascular prosthesis consisting of: a sheet member consisting of an antibiotic augmented ECM-mimicking composition, said antibiotic augmented ECM-mimicking composition consisting of poly(glycerol sebacate) (PGS), vancomycin, gentamicin and a basic fibroblast growth factor (bFGF).