MULTI-PIECE FLUID TRANSFER TIP
Improved pipette tips having sections, the pipette tips having a dis-assembled configuration and an assembled configuration. The dis-assembled configuration allows the pipette tips to be stored and transported when dis-assembled, saving space and allowing more convenient transport. The assembled configuration allows the full-sized pipette tips to be used in their most efficient form, without requiring additional space or difficult manipulation for their use. Cartridges carrying such improved pipette tips, systems including such improved pipette tips, kits providing such improved pipette tips, and methods for their use are disclosed. Cartridges and kits may also include or provide reagents, implements, samples, and combinations thereof, along with the improved pipette tips. The improved pipette tips provide advantages including improved fit within cartridges effective for ready insertion into automated sample analysis devices and systems.
1 . A fluid transfer device comprising:
a first section having a first internal bore, a proximal portion configured to operably engage with a fluid handling apparatus of an automated sample analysis device, and a distal portion, and
a second section having a second internal bore, a proximal portion configured to operably engage with said distal portion of said first section, and a distal portion comprising a tip having an aperture fluidically connected with said second internal bore,
said first section and said second section being configured for assembly together in an assembled configuration, wherein in said assembled configuration the distal portion of the first section is operably engaged with said proximal portion of said second section, effective to provide an assembled fluid transfer device;
wherein in said assembled fluid transfer device said first internal bore is fluidically connected with said second internal bore, whereby said assembled fluid transfer device comprises a composite internal bore comprising the first internal bore and the second internal bore, wherein said composite internal bore provides a continuous fluid connection between said aperture and said a proximal portion of the first section.
2 . The fluid transfer device of claim 1 , wherein said distal portion of said first section is configured to fit within said proximal portion of said second section, thereby providing operable engagement between said first and second sections to provide a fluid transfer device in said assembled configuration.
3 . The fluid transfer device of claim 1 , wherein said proximal portion of said second section is configured to fit within said distal portion of said first section, thereby providing operable engagement between said first and second sections to provide a fluid transfer device in said assembled configuration.
4 . A system comprising the fluid transfer device of claim 1 and a cartridge, said cartridge configured to hold said fluid transfer device in a dis-assembled configuration, wherein the cartridge holds each of said first section and said second section of the fluid transfer device separately.
5 . The system of claim 4 , wherein said cartridge is configured to hold a plurality of fluid transfer devices.
6 . The system of claim 5 , wherein said cartridge holds each of said plurality of fluid transfer devices in a dis-assembled configuration.
7 . A system comprising:
the fluid transfer device of claim 1 ;
a cartridge, said cartridge configured to hold said fluid transfer device in a dis-assembled configuration, wherein the cartridge holds each of said first section and said second section of the fluid transfer device separately; and
an automated sample analysis device.
8 . The system of claim 7 , wherein said cartridge is configured to hold a plurality of fluid transfer devices.
9 . The system of claim 8 , wherein said cartridge holds each of said plurality of fluid transfer devices in a dis-assembled configuration.
10 . A kit containing a fluid transfer device of claim 1 , a cartridge configured to hold said fluid transfer device in a dis-assembled configuration, wherein the cartridge holds each of said first section and said second section of the fluid transfer device separately, and instructions for the use of said fluid transfer device.
11 . A kit containing a fluid transfer device of claim 1 , a cartridge configured to hold said fluid transfer device in a dis-assembled configuration, wherein the cartridge holds each of said first section and said second section of the fluid transfer device separately, and a reagent for use in an assay performed by an automated sample analysis device.
12 . A method of delivering a fluid transfer device to an automated sample analysis device, comprising:
Placing a first section of a fluid transfer device in a cartridge, wherein said cartridge is configured to operably engage with an automated sample analysis device;
Placing a second section of a fluid transfer device in said cartridge;
Engaging said cartridge with said automated sample analysis device, effective to deliver said fluid transfer device to said automated sample analysis device.
13 . The method of claim 12 , wherein said engaging said cartridge with said automated sample analysis device comprises inserting at least a portion of said cartridge into said automated sample analysis device.
14 . The method of claim 12 , further comprising said automated sample analysis device assembling said fluid transfer device effective to provide an assembled fluid transfer device.
15 . The method of claim 14 , further comprising said automated sample analysis device performing an assay, wherein performance of said assay by said automated sample analysis device comprises use of said assembled fluid transfer device.
16 . The method of claim 12 , wherein said cartridge further comprises a reagent for use in an assay performed by said automated sample analysis device.
17 . The method of claim 15 , further comprising said automated sample analysis device performing an assay, wherein performance of said assay by said automated sample analysis device comprises use of said fluid transfer device in an assembled configuration.
18 . The method of claim 15 , further comprising said automated sample analysis device performing an assay, wherein performance of said assay by said automated sample analysis device comprises use of said reagent.
19 . The method of claim 15 , further comprising said automated sample analysis device performing an assay, wherein performance of said assay by said automated sample analysis device comprises use of said fluid transfer device in an assembled configuration and use of said reagent.
20 . A fluid transfer device comprising:
a first section having a first internal bore, a proximal portion configured to operably engage with a fluid handling apparatus of an automated sample analysis device, and a distal portion,
a second section having a second internal bore, a proximal portion configured to operably engage with said distal portion of said first section, and a distal portion, and
a third section having a third internal bore, a proximal portion configured to operably engage with said distal portion of said second section, and a distal portion comprising a tip having an aperture fluidically connected with said third internal bore,
said first section, said second section, and said third section being configured for assembly together in an assembled configuration, wherein in said assembled configuration the distal portion of the first section is operably engaged with said proximal portion of said second section, and said distal portion of the second section is operably engaged with said proximal portion of said third section, effective to provide an assembled fluid transfer device;
wherein in said assembled fluid transfer device said first internal bore is fluidically connected with said second internal bore and with said third internal bore; said second internal bore is fluidically connected with said first internal bore and with said third internal bore; and said third internal bore is fluidically connected with said first internal bore and with said second internal bore;
whereby said assembled fluid transfer device comprises a composite internal bore comprising the first internal bore, the second internal bore, and the third internal bore, wherein said composite internal bore provides a continuous fluid connection between said aperture and said a proximal portion of the first section.
21 . The fluid transfer device of claim 20 , wherein said distal portion of said first section is configured to fit within said proximal portion of said second section, and wherein said distal portion of said second section is configured to fit within said proximal portion of said third section, thereby providing operable engagement between said first, second, and third sections to provide a fluid transfer device in said assembled configuration.
22 . The fluid transfer device of claim 20 , wherein said proximal portion of said second section is configured to fit within said distal portion of said first section, and wherein said proximal portion of said third section is configured to fit within said distal portion of said second section, thereby providing operable engagement between said first, second, and third sections to provide a fluid transfer device in said assembled configuration.
23 . The fluid transfer device of claim 20 , wherein said proximal portion of said second section is configured to fit within said distal portion of said first section, and wherein said distal portion of said second section is configured to fit within said proximal portion of said third section, thereby providing operable engagement between said first, second, and third sections to provide a fluid transfer device in said assembled configuration.
24 . The fluid transfer device of claim 20 , wherein said distal portion of said first section is configured to fit within said proximal portion of said second section, and wherein said proximal portion of said third section is configured to fit within said distal portion of said second section, thereby providing operable engagement between said first, second, and third sections to provide a fluid transfer device in said assembled configuration.