Pharmaceutical compositions comprising sorbitan esters
View Patent ↗The present invention relates to a pharmaceutical composition comprising sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.
1. A method for treating schizophrenia, bipolar disorder, or depression in a subject in need thereof comprising administering to the subject an effective amount of a pharmaceutical composition comprising:
(a) compound A-7:
(b) sorbitan laurate;
(c) polysorbate 20; and
(d) an aqueous vehicle,
wherein the composition forms an aqueous, flocculated, injectable suspension.
2. The method of claim 1 , wherein depression is treated.
3. The method of claim 1 , wherein bipolar disorder is treated.
4. The method of claim 1 , wherein schizophrenia is treated.
5. The method of claim 1 , wherein the ratio of components (b) to (c) is approximately 5 to 2, by weight.
6. The method of claim 1 , comprising about 0.2- 1 weight percent sorbitan laurate.
7. The method of claim 1 , comprising about 0.4- 0.7 weight percent sorbitan laurate.
8. The method of claim 1 , comprising about 0.5 weight percent sorbitan laurate.
9. The method of claim 1 , comprising about 0.05- 0.8 weight percent polysorbate 20.
10. The method of claim 1 , comprising about 0.1- 0.3 weight percent polysorbate 20.
11. The method of claim 1 , comprising about 0.2 weight percent polysorbate 20.
12. The method of claim 1 , comprising approximately 15- 35 weight percent compound A-7.
13. The method of claim 1 , comprising approximately 20- 30 weight percent compound A-7.
14. A method for treating schizophrenia, bipolar disorder, or depression in a subject in need thereof comprising administering to the subject an injectable pharmaceutical composition comprising:
(a) 15-35 weight percent compound A-7:
(b) approximately 0.2-1 weight percent sorbitan laurate;
(c) approximately 0.05-0.8 weight percent polysorbate 20; and
(d) an aqueous carrier.
15. The method of claim 14 , wherein schizophrenia is treated.
16. A method for treating schizophrenia, bipolar disorder, or depression in a subject in need thereof comprising administering to the subject an injectable composition comprising:
(a) compound A-7:
(b) sorbitan laurate;
(c) polysorbate 20; and
(d) an aqueous vehicle.
17. The method of claim 16 , wherein the composition further comprises a buffer.
18. The method of claim 17 , wherein the buffer is a phosphate, citrate, tartrate or acetate buffer.
19. The method of claim 16 , wherein schizophrenia is treated.
20. A method for treating schizophrenia, bipolar disorder, or depression in a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising:
(a) 24-30 weight percent compound A-7:
(b) 0.2-1 weight percent sorbitan laurate;
(c) 0.1-0.3 weight percent polysorbate 20; and
(d) an aqueous vehicle.
21. The method of claim 20 , wherein schizophrenia is treated.