Systems and methods for calibration, verification, and sensitivity checks for detectors
The present disclosure is directed to methods and systems for calibration, calibration verification, and sensitivity checks for a detector. The methods and systems include calibrating a detector by releasing at least one calibrant from at least one calibrant chamber in flow communication with the detector. The systems and methods further include verifying the calibration by releasing at least one verification substance from at least one verification chamber in flow communication with the detector. The systems and methods further include checking a sensitivity of the detector by releasing at least one sensitivity substance from at least one sensitivity chamber in flow communication with the detector.
1. A method for internally performing a calibration and a verification of a detector in a mobility spectrometer, the method comprising:
performing the calibration of the detector, wherein the calibration comprises releasing at least one calibrant in a form of a gas from at least one calibrant chamber in flow communication with the detector, generating a calibration signal using the at least one calibrant, comparing the calibration signal to an expected signal, and, based on the comparing, determining a calibration unit for use in processing future detected signals;
performing the verification of the calibration, wherein the verification comprises
releasing at least one verification substance in a form of a gas from at least one verification chamber in flow communication with the detector, wherein the at least one verification substance has at least one predefined mobility spectrum and wherein the at least one verification chamber and at least one calibrant chamber are separate chambers;
ionizing the at least one verification substance to generate a verification signal;
automatically adjusting at least one mobility spectrum of the at least one ionized verification substance by at least a portion of the calibration unit wherein the at least one mobility spectrum includes at least one peak;
recording the at least one mobility spectrum of the at least one ionized verification substance; and
generating a verification signal, adjusting the verification signal using the calibration unit, comparing the adjusted verification signal to an expected signal, and, based on the comparing, verifying the calibration or repeating the calibration.
2. The method of claim 1 , wherein the calibration comprises:
ionizing the at least one calibrant to generate the calibration signal; and
recording at least one mobility spectrum of the at least one ionized calibrant, wherein the at least one mobility spectrum includes at least one peak.
3. The method of claim 1 , wherein the verification further comprises:
verifying an adjusted drift time of the at least one peak; and
recording the adjusted drift time.
4. A method for performing a calibration, verification, and sensitivity checking of a detector in a mobility spectrometer, the method comprising:
performing the calibration of the detector, wherein the calibration comprises releasing at least one calibrant in a form of a gas from at least one calibrant chamber in flow communication with the detector, generating a calibration signal using the at least one calibrant, comparing the calibration signal to an expected signal, and determining a calibration unit for use in adjusting future detected signals;
performing the verification of the calibration, wherein the verification comprises
releasing at least one verification substance in a form of a gas from at least one verification chamber in flow communication with the detector, wherein the at least one verification substance has at least one predefined mobility spectrum and wherein the at least one verification chamber and at least one calibrant chamber are separate chambers;
ionizing the at least one verification substance to generate the verification signal;
automatically adjusting at least one mobility spectrum of the at least one ionized verification substance by at least a portion of the calibration unit wherein the at least one mobility spectrum includes at least one peak;
recording the at least one mobility spectrum of the at least one ionized verification substance;
comparing the adjusted verification signal to an expected signal; and,
based on the comparing, verifying the calibration or repeating the calibration; and,
checking the sensitivity of the detector, wherein the sensitivity checking comprises releasing at least one sensitivity substance in a form of a gas from at least one sensitivity chamber in flow communication with the detector.
5. The method of claim 4 , wherein releasing the at least one sensitivity substance comprises releasing a predetermined quantity of the at least one sensitivity substance.
6. The method of claim 4 , wherein checking the sensitivity comprises:
ionizing the at least one sensitivity substance; and
recording at least one mobility spectrum of the at least one ionized sensitivity substance, wherein the at least one mobility spectrum includes at least one peak.
7. The method of claim 6 , wherein checking the sensitivity further comprises comparing the at least one mobility spectrum to at least one pre-determined mobility spectrum of the at least one sensitivity substance.
8. The method of claim 4 , wherein the calibration comprises:
ionizing the at least one calibrant; and
recording at least one mobility spectrum of the at least one ionized calibrant, wherein the at least one mobility spectrum includes at least one peak.
9. A method for performing a calibration, a verification, and a sensitivity check of a detector in a mobility spectrometer, the method comprising:
performing the calibration of the detector by releasing at least one calibrant in a form of a gas from at least one calibrant chamber in flow communication with the detector, generating a calibration signal using the at least one calibrant, comparing the calibration signal to an expected signal, and determining a calibration unit for use in adjusting future detected signals;
performing the verification of the calibration, wherein the verification comprises
releasing at least one verification substance in a form of a gas from at least one verification chamber in flow communication with the detector, wherein the at least one verification substance has at least one predefined mobility spectrum;
ionizing the at least one verification substance to generate a verification signal;
automatically adjusting at least one mobility spectrum of the at least one ionized verification substance by at least a portion of the calibration unit wherein the at least one mobility spectrum includes at least one peak;
recording the at least one mobility spectrum of the at least one ionized verification substance;
comparing the adjusted verification signal to an expected signal; and,
based on the comparing, verifying the calibration or repeating the calibration; and
performing the sensitivity check of the detector, wherein the sensitivity check comprises releasing at least one sensitivity substance in a form of a gas from at least one sensitivity chamber in flow communication with the detector, wherein the at least one verification chamber and at least one sensitivity chamber are separate chambers, generating a sensitivity check signal using the at least one sensitivity substance, determining if the sensitivity check signal has an expected magnitude, and, based on the determining, confirming the sensitivity of the detector or determining the detector requires servicing.
10. The method of claim 9 , wherein releasing the at least one sensitivity substance comprises releasing a predetermined quantity of the at least one sensitivity sub stance.
11. The method of claim 9 , wherein performing the sensitivity check further comprises:
ionizing the at least one sensitivity substance to generate the sensitivity check signal; and
recording at least one mobility spectrum of the at least one ionized sensitivity substance, wherein the at least one mobility spectrum includes at least one peak.