PREDICTING AN ONSET OF APNEA
A device is disclosed that can predict an onset of an apnea or disordered breathing in a patient. The device can include a number of contacts adapted to make contact with the patient's tongue, and a control circuit configured to receive a first signal from the number of contacts, and predict an onset of an apnea or disordered breathing in the patient based, at least in part, on one or more characteristics of the first signal at a first time.
1 . A device comprising:
a number of contacts adapted to make contact with the patient's tongue; and
a control circuit coupled to the contacts and configured to:
receive a first signal from the number of contacts;
predict an onset of an apnea or disordered breathing in the patient based, at least in part, on one or more characteristics of the first signal at a first time; and
prior to the onset of the apnea or disordered breathing, provide electrical stimulation via the number of contacts to one or more portions of the patient's upper airway based on the prediction of the onset of the apnea or disordered breathing.
2 . The device of claim 1 , wherein the control circuit is configured to:
in a first mode, receive the first signal from the number of contacts; and
in a second mode, provide a stimulation waveform to the number of contacts, the stimulation waveform configured to provide electrical stimulation to one or more portions of the patient's upper airway.
3 . The device of claim 2 , wherein the electrical stimulation is configured to target the patient's Palatoglossus muscle and to avoid targeting the patient's Hypoglossal nerve.
4 . The device of claim 1 , wherein a portion of two of the contacts are adapted to be positioned on opposites side of the tongue posterior to a last molar location of the patient.
5 . The device of claim 1 , wherein the first signal comprises one or more electromyogram (EMG) signals.
6 . The device of claim 1 , wherein the number of contacts are affixed to a dental appliance adapted to fit within the patient's oral cavity.
7 . The device of claim 1 , wherein the control circuit is further configured to:
receive second signals from one or more sensors; and
predict the onset of the apnea or disordered breathing in the patient based on a combination of the first and second signals.
8 . The device of claim 7 , wherein the one or more sensors includes a thermistor.
9 . The device of claim 7 , wherein the first signal comprises an indication of one or more states of the patient's upper airway, and the second signals comprise an indication of airflow in the patient's upper airway.
10 . The device of claim 7 , wherein:
the first signal comprises an indication of at least one of electrical activity in the patient's upper airway, movement of the patient's upper airway, and a change in the patient's respiration rate; and
the second signals comprise an indication of at least one of an indication of an airflow in the patient's upper airway, an oxygenation rate, a level of carbon dioxide, a movement of the patient's chest, a movement of the patient's abdomen, and sounds emanating from the patient's upper airway.
11 . The device of claim 1 , wherein the control circuit is configured to predict the onset of apnea or disordered breathing based, at least in part, on a magnitude of the first signal varying by more than an amount during a time period.
12 . The device of claim 11 , wherein the time period comprises a respiratory cycle of the patient.
13 . The device of claim 1 , wherein the control circuit is further configured to:
after providing the electrical stimulation, detect a presence of apnea or disordered breathing in the patient based, at least in part, on one or more characteristics of the first signal at a second time.
14 . The device of claim 1 , wherein the control circuit is configured to predict the onset of apnea or disordered breathing based on a comparison between the first signal and one or more reference signals stored in the device.
15 . A method comprising:
receiving, from a number of contacts positioned within an oral cavity of a patient, a first signal indicative of one or more states of the patient's upper airway;
predicting an onset of an apnea or disordered breathing in the patient based, at least in part, on one or more characteristics of the first signal at a first time; and
prior to the onset of the apnea or disordered breathing, providing electrical stimulation via the number of contacts to one or more portions of the patient's upper airway based on the prediction of the onset of the apnea or disordered breathing.
16 . The method of claim 15 , further comprising:
in a first mode, receiving the first signal from the number of contacts; and
in a second mode, providing a stimulation waveform to the number of contacts, the stimulation waveform configured to provide electrical stimulation to one or more portions of the patient's upper airway.
17 . The method of claim 15 , wherein the electrical stimulation is configured to target the patient's Palatoglossus muscle and to avoid targeting the patient's Hypoglossal nerve.
18 . The method of claim 15 , wherein a portion of two of the contacts are adapted to be positioned on opposites side of the tongue posterior to a last molar location of the patient.
19 . The method of claim 15 , wherein the first signal comprises one or more electromyogram (EMG) signals.
20 . The method of claim 15 , wherein the number of contacts are affixed to a removable dental appliance adapted to fit within the patient's oral cavity.
21 . The method of claim 15 , further comprising:
receiving second signals from one or more sensors; and
predicting the onset of the apnea or disordered breathing in the patient based on a combination of the first and second signals.
22 . The method of claim 21 , wherein the one or more sensors includes a thermistor.
23 . The method of claim 21 , wherein the first signal comprises an indication of one or more states of the patient's upper airway, and the second signals comprise an indication of airflow in the patient's upper airway.
24 . The method of claim 15 , wherein:
the first signal comprises an indication of at least one of electrical activity in the patient's upper airway, movement of the patient's upper airway, and a change in the patient's respiration rate; and
the second signals comprise an indication of at least one of an indication of an airflow in the patient's upper airway, an oxygenation rate, a level of carbon dioxide, a movement of the patient's chest, a movement of the patient's abdomen, and sounds emanating from the patient's upper airway.
25 . The method of claim 15 , wherein predicting the onset of apnea or disordered breathing comprises determining whether a magnitude of the first signal varies by more than an amount during a time period.
26 . The method of claim 25 , wherein the time period comprises a respiratory cycle of the patient.
27 . The method of claim 15 , further comprising:
after providing the electrical stimulation, detecting a presence of apnea or disordered breathing in the patient based, at least in part, on one or more characteristics of the first signal at a second time.
28 . The method of claim 15 , wherein predicting the onset of apnea or disordered breathing is based on a comparison between the first signal and one or more reference signals stored in the device.