Use of PEO-PBO block copolymers in ophthalmic compositions
The use of poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses. Such compounds are also useful for cleaning purposes. The use of the compounds as surfactants in various types of compositions for treating contact lenses therefore represents a preferred embodiment of the present invention.
1. A contact lens product, comprising a package; and a packaging solution for storing a silicone hydrogel contact lens, wherein the packaging solution comprises 0.001 w/v % to about 1 w/v % of at least one poly(oxyethylene)-poly(oxybutylene) block copolymer having a molecular weight in the range of 500 to 100,000 Daltons, and having an osmolality of 200 to 400 milliosmoles/kilogram.
2. The contact lens product according to claim 1 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer is of the formula (EO) m (BO) n , wherein EO is oxyethylene and BO is oxybutylene, and wherein m is an integer having an average value of 10 to 1000 and n is an integer having an average value of 5 to 1000.
3. The contact lens product according to claim 2 , wherein m is greater than n.
4. The contact lens product according to claim 3 , wherein the ratio of m to n is in the range of about 2:1 to about 6:1.
5. The contact lens product according to claim 4 , wherein the ratio of m to n is in the range of about 3:1 to about 6:1.
6. The contact lens product according to claim 5 , wherein the average value of m is 45 and the average value of n is 10.
7. The contact lens product according to claim 1 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer has a molecular weight in the range of 1,000 to 50,000 Daltons.
8. The contact lens product according to claim 7 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer has a molecular weight in the range of 2,000 to 10,000 Daltons.
9. The contact lens product according to claim 1 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer is of the formula
Wherein R is selected from the group consisting of hydrogen, methyl, ethyl, propyl and butyl; m is an integer having an average value of 10 to 1000; and n is an integer having an average value of 5 to 1000.
10. The contact lens product according to claim 9 , wherein R is methyl; m has an average value of 45; and n has an average value of 10.