Foamable compositions, breakable foams and their uses
View Patent ↗A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free foamable compositions.
1. A foamable composition comprising:
an active agent consisting of one or more antibiotic agents;
at least about 60% by weight of a short chain alcohol;
a foaming booster, wherein the foaming booster is a polymeric agent;
between about 2% and about 50% of at least one organic carrier selected from the group consisting of a polar solvent, a hydrophobic organic carrier, and a mixture thereof;
an active herbal extract;
a metal; and
an antioxidant;
wherein the foamable composition is a surfactant free composition.
2. The foamable composition according to claim 1 , wherein the one or more antibiotic agents is a tetracycline antibiotic or a salt, ion, or complex thereof.
3. The foamable composition according to claim 1 , wherein the one or more antibiotic agents are about 0.1% to about 5% by weight of the composition.
4. The foamable composition according to claim 3 , wherein the one or more antibiotic agents are about 1% by weight of the composition.
5. The foamable composition according to claim 3 , wherein the one or more antibiotic agents are about 5% by weight of the composition.
6. The foamable composition according to claim 1 , wherein the antioxidant is about 0.1% to about 10% by weight of the composition.
7. The foamable composition according to claim 1 , wherein the short chain alcohol is ethanol.
8. The foamable composition according to claim 1 , wherein the at least one organic carrier is a polar solvent.
9. The foamable composition according to claim 8 , wherein the polar solvent is propylene glycol.
10. The foamable composition according to claim 1 , wherein the polymeric agent is a cellulose ether.
11. The foamable composition according to claim 10 , wherein the cellulose ether is a hydroxypropyl cellulose.
12. The foamable composition according to claim 8 , wherein the polar solvent is about 5% to about 25% by weight of the composition.
13. The foamable composition according to claim 12 , wherein the polar solvent is about 17% to about 23% by weight of the composition.
14. The composition according to claim 2 , wherein the one or more antibiotic agents are present in a therapeutically effective concentration.
15. The foamable composition according to claim 1 , wherein the polymeric agent is about 0.1% to about 5% by weight of the composition.
16. The foamable composition according to claim 1 , wherein:
the one or more antibiotic agents is a tetracycline antibiotic or a salt, ion, or complex thereof; the short chain alcohol comprises ethanol; the polymeric agent comprises a cellulose ether; and the at least one organic carrier comprises a polar solvent, wherein the polar solvent comprises a glycol.
17. The foamable composition according to claim 16 , wherein:
the tetracycline antibiotic is about 0.1% to about 5% by weight of the composition;
the cellulose ether is about 0.1% to about 5% by weight of the composition;
the glycol is about 5% to about 25% by weight of the composition; and
the antioxidant is about 0.1% to about 10% by weight of the composition.
18. The composition according to claim 17 , wherein the tetracycline antibiotic is about 1% by weight of the composition.
19. The foamable composition according to claim 17 , wherein the cellulose ether is hydroxypropyl cellulose.
20. The foamable composition according to claim 19 , wherein the glycol is propylene glycol.
21. The foamable composition according to claim 1 , further comprising a liquefied or compressed gas propellant.
22. The foamable composition according to claim 17 , wherein:
the cellulose ether is a hydroxypropyl cellulose; and
the polar solvent is a propylene glycol.
23. A foamable composition comprising:
an active agent consisting of an antibiotic;
at least about 60% by weight of a short chain alcohol;
a polymeric agent; and
between about 2% and about 50% of at least one organic carrier selected from the group consisting of a polar solvent, a hydrophobic organic carrier, and a mixture thereof;
wherein the foamable composition comprises no surfactant.
24. A non-surfactant carrier composition comprising:
an active agent consisting of an antibiotic;
at least about 60% by weight of ethanol;
a cellulose ether;
a glycol;
an active herbal extract;
a metal; and
an antioxidant,
wherein the non-surfactant carrier composition is surfactant free.
25. The non-surfactant carrier composition according to claim 24 , wherein the glycol comprises propylene glycol between about 2% and about 50% by weight of the composition.
26. The foamable composition according to claim 23 , wherein the at least one organic carrier is about 17% to about 23% by weight of the composition.
27. The non-surfactant carrier composition according to claim 25 , wherein the glycol comprises propylene glycol between about 17% and about 23% by weight of the composition.
28. The foamable composition according to claim 13 , wherein the polar solvent is about 17% by weight of the composition.
29. The foamable composition according to claim 13 , wherein the polar solvent is about 23% by weight of the composition.
30. The non-surfactant carrier composition according to claim 24 , wherein:
the antibiotic is a tetracycline antibiotic or a salt, ion, or complex thereof, and is about 0.1% to about 5% by weight of the composition;
the cellulose ether is hydroxypropyl cellulose and is about 0.1% to about 5% by weight of the composition; and
the glycol is propylene glycol and is about 17% to about 23% by weight of the composition.
31. The non-surfactant carrier composition according to claim 30 , wherein the antioxidant is about 0.1% to about 10% by weight of the composition.
32. The non-surfactant carrier composition according to claim 30 , wherein the ethanol is at least about 65% by weight of the composition.
33. The foamable composition according to claim 17 , wherein the glycol is about 17% to about 23% by weight of the composition.