Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
View Patent ↗The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
1. A composition comprising mipomersen and eicosapentaenoic acid, wherein the composition comprises at least about 80%, by weight of all fatty acids (and/or derivatives thereof) present, eicosapentaenoic acid, and no more than about 20%, by weight of all fatty acids (and/or derivatives thereof) present, docosahexaenoic acid or ester thereof.
2. The composition of claim 1 , wherein the mipomersen is present in an amount less than, about equal to, or greater than an effective amount of mipomersen when administered as a monotherapy.
3. The composition of claim 1 , wherein the mipomersen comprises mipomersen nonadecasodium.
4. The composition of claim 1 , wherein the mipomersen is suspended in the eicosapentaenoic acid.
5. The composition of claim 1 , wherein the mipomersen is in the form of an injectable solution.
6. The composition of claim 1 , wherein the mipomersen is present in an amount of about 5 mg to about 2000 mg.
7. The composition of claim 1 , wherein the eicosapentaenoic acid is present in an amount of about 400 mg to about 5000 mg.
8. The composition of claim 1 , wherein the mipomersen is present in an amount of about 2 mg to about 10 mg and the eicosapentaenoic acid is present in an amount of about 400 mg to about 5000 mg.