Molded flow channel
A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.
1. A nanopore based sequencing system, comprising:
a plurality of nanopore sensors, each nanopore sensor having a portion for receiving a fluid;
a fluid chamber configured to guide the fluid over the plurality of nanopore sensors, wherein at least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode, wherein the material that has been molded around at least the portion of the electrode is an elastomer, wherein the material that has been molded around at least the portion of the electrode has been injection molded, and wherein the material that has been molded is configured to create raised dividers on a surface of the electrode configured to guide the fluid along a winding length of the fluid chamber; and
an inlet configured to deliver the fluid into the fluid chamber.
2. The nanopore based sequencing system of claim 1 , further comprising an outlet configured to deliver the fluid out of the fluid chamber.
3. The nanopore based sequencing system of claim 1 , wherein the fluid chamber forms a fluid flow channel that directs the fluid to flow above at least some of top portions of the nanopore sensors, and the fluid flow channel traverses above different nanopore sensors along a length of the fluid flow channel.
4. The nanopore based sequencing system of claim 1 , wherein the electrode is a counter electrode of the nanopore based sequencing system.
5. The nanopore based sequencing system of claim 1 , wherein the material that has been molded forms at least a portion of a channel of the inlet.
6. The nanopore based sequencing system of claim 1 , wherein the electrode was connected to a tab portion that has been removed.
7. The nanopore based sequencing system of claim 1 , wherein the material that has been molded is to leave an opening exposing a surface of the electrode outside the fluid chamber and an electrical potential source is electrically connected to the electrode via an electrical contact through the opening.
8. The nanopore based sequencing system of claim 1 , wherein the material that has been molded is clamped to a surface of a chip with the nanopore sensors using a clamping component.
9. A nanopore based sequencing system, comprising:
a plurality of nanopore sensors, each nanopore sensor having a portion for receiving a fluid;
a fluid chamber configured to guide the fluid over the plurality of nanopore sensors, wherein at least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode, wherein the electrode includes an opening that has been filled with the material that has been molded around at least the portion of the electrode; and
an inlet configured to deliver the fluid into the fluid chamber.
10. A nanopore based sequencing system, comprising:
a plurality of nanopore sensors, each nanopore sensor having a portion for receiving a fluid;
a fluid chamber configured to guide the fluid over the plurality of nanopore sensors, wherein at least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode, wherein the material that has been molded around at least the portion of the electrode is an elastomer, and wherein the material that has been molded is configured to create raised dividers on a surface of the electrode configured to guide the fluid along a winding length of the fluid chamber, and wherein at least a portion of the electrode is exposed inside the fluid chamber; and
an inlet configured to deliver the fluid into the fluid chamber.
11. A nanopore based sequencing system, comprising:
a plurality of nanopore sensors, each nanopore sensor having a portion for receiving a fluid;
a fluid chamber configured to guide the fluid over the plurality of nanopore sensors, wherein at least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode; and
an inlet configured to deliver the fluid into the fluid chamber, wherein a channel of the inlet passes through the electrode.
12. A nanopore based sequencing system, comprising:
a plurality of nanopore sensors, each nanopore sensor having a portion for receiving a fluid;
a fluid chamber configured to guide the fluid over the plurality of nanopore sensors, wherein at least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode, wherein the material that has been molded around at least the portion of the electrode is an elastomer, and wherein the material that has been molded is configured to create raised dividers on a surface of the electrode configured to guide the fluid along a winding length of the fluid chamber, wherein the electrode is at least in part made of titanium nitride; and
an inlet configured to deliver the fluid into the fluid chamber.
13. A nanopore based sequencing system, comprising:
a plurality of nanopore sensors, each nanopore sensor having a portion for receiving a fluid;
a fluid chamber configured to guide the fluid over the plurality of nanopore sensors, wherein at least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode; and
an inlet configured to deliver the fluid into the fluid chamber, wherein the material that has been molded is clamped to a surface of a chip with the nanopore sensors using a clamping component with an opening to accommodate the inlet.
14. A nanopore based sequencing system, comprising:
a plurality of nanopore sensors, each nanopore sensor having a portion for receiving a fluid;
a fluid chamber configured to guide the fluid over the plurality of nanopore sensors, wherein at least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode, wherein the material that has been molded is compressed to a surface of a chip with the nanopore sensors using a clamping component that is clamped to a circuit board; and
an inlet configured to deliver the fluid into the fluid chamber.
15. A nanopore based sequencing system, comprising:
a plurality of nanopore sensors, each nanopore sensor having a portion for receiving a fluid;
a fluid chamber configured to guide the fluid over the plurality of nanopore sensors, wherein at least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode;
an inlet configured to deliver the fluid into the fluid chamber; and
an encapsulant that encapsulates wire bonds between a circuit board and a chip including the nanopore sensors.
16. A nanopore based sequencing system, comprising:
a plurality of nanopore sensors, each nanopore sensor having a portion for receiving a fluid;
a fluid chamber configured to guide the fluid over the plurality of nanopore sensors, wherein at least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode;
an inlet configured to deliver the fluid into the fluid chamber; and
a plurality of wire bonds between a circuit board and a chip including the nanopore sensors and the material that has been molded are encapsulated together in a same encapsulant.
17. A method for building a nanopore based sequencing system, comprising:
placing an electrode insert inside a mold;
injecting a molding material into the mold to couple the molding material to the electrode insert;
removing a molded component including the electrode insert and the molding material from the mold; and
coupling the molded component to a nanopore sensor chip.