Nitric oxide topical application apparatus and methods
A topical application of nitric oxide may be provided by two separate containers, each containing an active component media to produce nitric oxide when combined. For example, a nitrite component media may be contained in one dispenser and an acidified component media may be contained in another dispenser. Each dispenser may dispense the respective component media as a foam. The resultant foams are combined to initiate the production of nitric oxide and the mixture of foams is applied topically to treat various skin disorders or wounds.
1. A method for treating skin disorders comprising:
providing a first solution comprising water, at least one nitrite reactant, and a cationic surfactant;
providing a second solution comprising water, at least one acidic reactant, and the cationic surfactant;
dispensing a portion of the first solution in a manner that produces a first foam;
dispensing a portion of the second solution in a manner that produces a second foam;
mixing the first foam and the second foam to produce a resultant foam;
applying the resultant foam to a portion of skin to be treated; and
allowing the resultant foam to collapse.
2. The method of claim 1 , further comprising:
allowing the resultant foam to remain on the portion of skin for at least three minutes; and
removing any remaining resultant foam from the portion of skin.
3. The method of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, and 1 g of the cationic surfactant; and
the second solution comprises approximately 100 mL of water, 5 g of lactic acid, 6 g of citric acid, and 3 g of the cationic surfactant.
4. The method of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, 2 g of sodium bicarbonate, and 1 g of the cationic surfactant; and
the second solution comprises approximately 100 mL of water, 5 g of lactic acid, 8 g of citric acid, and 3 g of the cationic surfactant.
5. The method of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, and 2 g of the cationic surfactant; and
the second solution comprises approximately 100 mL of water, 10 g of citric acid, and 6 g of the cationic surfactant.
6. The method of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, 2 g of sodium bicarbonate, and 2 g of the cationic surfactant; and
the second solution comprises approximately 100 mL of water, 5 g of ascorbic acid, 8 g of citric acid, and 6 g of the cationic surfactant.
7. The method of claim 3 , further comprising:
allowing the resultant foam to remain on the portion of skin for at least three minutes; and
removing any remaining resultant foam from the portion of skin.
8. The method of claim 7 , wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 90% and 120% during the time the resultant foam remains on the portion of skin.
9. The method of claim 6 , further comprising:
allowing the resultant foam to remain on the portion of skin for at least three minutes; and
removing any remaining resultant foam from the portion of skin.
10. The method of claim 7 , wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70% during the time the resultant foam remains on the portion of skin.
11. A method for treating skin disorders comprising:
providing a first solution comprising approximately 100 mL of water, 10 g of a nitrite reactant, and 2 g of a cationic surfactant;
providing a second solution comprising approximately 100 mL of water, 10 g of an acidic reactant, and 6 g of the cationic surfactant;
dispensing a portion of the first solution in a manner that produces a first foam;
dispensing a portion of the second solution in a manner that produces a second foam;
mixing the first foam and the second foam to produce a resultant foam;
applying the resultant foam to a portion of skin to be treated; and
allowing the resultant foam to remain on the portion of skin for at least three minutes wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70% during the time the resultant foam remains on the portion of skin.
12. The method of claim 11 , wherein the nitrite reactant is selected from the group consisting of sodium nitrite and potassium nitrite, and the acidic reactant is selected from the group consisting of citric acid, lactic acid, salicylic acid, phosphoric acid, and ascorbic acid.
13. The method of claim 11 , wherein the first solution further comprises approximately 2 g of sodium bicarbonate.
14. The method of claim 11 , wherein the first solution further comprises a salt buffer for regulating the reaction rate of nitric oxide production.
15. A method for topical application comprising:
providing a first solution comprising approximately 100 mL of water, 10 g of a nitrite reactant, and 2 g of a cationic surfactant;
providing a second solution comprising approximately 100 mL of water, 10 g of an acidic reactant, and 6 g of the cationic surfactant;
dispensing a portion of the first solution in a manner that produces a first foam;
dispensing a portion of the second solution in a manner that produces a second foam;
mixing the first foam and the second foam to produce a resultant foam, wherein the resultant foam produces nitric oxide;
applying the resultant foam to a portion of skin to be treated; and
allowing the resultant foam to collapse in response to contact with the portion of skin.
16. The method of claim 15 , further comprising, allowing the resultant foam to remain on the portion of skin for at least three minutes.
17. The method of claim 16 , wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70% during the time the resultant foam remains on the portion of skin.
18. The method of claim 15 , wherein the first solution further comprises approximately 2 g of sodium bicarbonate.
19. The method of claim 15 , wherein the first solution further comprises a salt buffer for regulating the reaction rate of nitric oxide production.