Extended release, abuse deterrent pharmaceutical compositions

1. A solid dosage form comprising at least one active pharmaceutical ingredient (API) or a pharmaceutically acceptable salt thereof, 2% to 4% by weight of at least one carbomer, 26% to 45% by weight of at least one cellulose ether, 15% to 25% by weight of at least one polyethylene oxide, 5% to 15% by weight of at least one organic acid, and 1% to 10% by weight of at least one sugar alcohol, wherein the dosage form is humidified at a relative humidity of about 65% to about 85% at about 25° C. and heated to a temperature from about 60° C. to about 90° C.

2. The solid dosage form of claim 1 , which comprises two cellulose ethers, and the two cellulose ethers are a hydroxypropyl cellulose and a hydroxypropyl methyl cellulose.

3. The solid dosage form of claim 1 , wherein the API is an opioid or a combination of an opioid and a non-opioid analgesic.

4. The solid dosage form of claim 3 , wherein the opioid is oxycodone, oxymorphone, hydrocodone, hydromorphone, codeine, or morphine.

5. The solid dosage form of claim 1 , which is a tablet, and optionally comprises a film coating.

6. The solid dosage form of claim 5 , which has a breaking strength of less than about 400 N.

7. The solid dosage form of claim 1 , which has an in vitro release of no more than about 80% of the API within about 6 hours.

8. The solid dosage form of claim 1 , which has abuse deterrent properties.

9. The solid dosage form of claim 8 , which deters abuse by breaking into a plurality of particles having an average diameter of greater than about 250 microns when crushed, ground, or pulverized.

10. The solid dosage form of claim 8 , which deters abuse by forming a viscous mixture or gel when contacted with from about 1 mL to about 10 mL of an aqueous solvent.

11. The solid dosage form of claim 1 , which further comprises 0.1% to 3% by weight at least one lubricant.

12. The solid dosage form of claim 11 , wherein the at least one lubricant is magnesium stearate or colloidal silicon dioxide.