CYCLOSPORIN COMPOSITIONS
Disclosed herein are therapeutic methods, compositions, and medicaments related to cyclosporine.
1 .- 20 . (canceled)
21 . A method comprising topically administering an aqueous solution comprising cyclosporin A to an eye of a mammal in need thereof to enhance or restore lacrimal gland tearing.
22 . The method of claim 21 , wherein said method increases tear production in a tear-deficient eye.
23 . The method of claim 21 , wherein said method is effective in treating keratoconjunctivitis sicca.
24 . The method of claim 21 , wherein said method is effective in treating dry eye disease.
25 . The method of claim 21 wherein the mammal is a human patient, and wherein less than 10% of human patients suffer burning or stinging when said aqueous solution is administered only once a day for a period of three months.
26 . The method of claim 21 wherein the mammal is a human patient, and wherein less than 10% of human patients suffer ocular burning when said aqueous solution is administered only once a day for a period of three months.
27 . The method of claim 21 wherein the aqueous solution is administered only once a day.
28 .- 39 . (canceled)
40 . The method of claim 21 , wherein the cyclosporin A is present in the aqueous solution at a concentration of from about 0.0001% (w/v) to less than about 0.05% (w/v).