Pharmaceutical compositions and methods of using the same
View Patent ↗Novel pharmaceutical compositions including cocaine hydrochloride and methods of treating patients using those pharmaceutical compositions are described.
1. A method for induction of local anesthesia prior to performing a diagnostic procedure on, through, or adjacent a mucous membrane of the nasal cavities of a patient comprising:
soaking a plurality of absorbent articles with an aqueous solution comprising, by weight, about 4% cocaine hydrochloride, greater than 0 to less than about 0.150% citric acid, and about 0.07% to about 0.20% sodium benzoate; and
contacting the absorbent articles with the mucous membrane in a nasal cavity against a septum of the patient for up to about 20 minutes to reduce sensation in a body region of the patient, provided that the method results in an absorptivity factor for cocaine in the patient ranging from about 0.640 h −1 to about 0.687 h −1 .
2. The method of claim 1 , wherein the diagnostic procedure comprises nasal endoscopy.
3. The method of claim 2 , wherein the diagnostic procedure comprises nasal endoscopy with debridement.
4. The method of claim 1 , wherein the diagnostic procedure comprises laryngoscopy.
5. The method of claim 4 , wherein the diagnostic procedure comprises nasal laryngoscopy.
6. The method of claim 4 , wherein the diagnostic procedure comprises nasopharyngeal laryngoscopy.
7. The method of claim 1 , wherein the diagnostic procedure comprises transnasal esophagoscopy.
8. The method of claim 1 , wherein the diagnostic procedure comprises nasal stroboscopy.
9. A method of administering a topical localized anesthetic composition to a patient comprising:
soaking a plurality of absorbent articles with an aqueous solution comprising, by weight, about 4% cocaine hydrochloride, greater than 0 to less than about 0.150% citric acid, and about 0.07% to about 0.20% sodium benzoate; and
contacting the absorbent articles with a nasal mucous membrane in a nasal cavity against a septum of the patient for up to about 20 minutes, provided that the method results in an absorptivity factor for cocaine in the patient ranging from about 0.640 h −1 to about 0.687 h −1 .
10. The method of claim 9 , wherein the absorbent articles comprise pledgets.
11. The method of claim 10 , wherein the pledgets comprise four pledgets.
12. The method of claim 11 , wherein the four pledgets are soaked in the pharmaceutical composition for at least ten minutes prior to contacting the nasal mucous membrane.
13. The method of claim 10 , wherein the pledgets comprise cottonoid pledgets.
14. The method of claim 13 , wherein each of the cottonoid pledgets retains up to 90% of the pharmaceutical composition when removed from contact with the nasal mucous membrane.