Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof

1. A method for regulating Tie-2 receptor activation in a subject in need thereof, comprising administering to the subject a therapeutically-effective amount of a humanized form of R15E6 that activates the Tie-2 receptor, wherein administration of the humanized form of R15E6 to the subject activates the Tie-2 receptor in the presence of Ang1.

2. The method of claim 1 , wherein the humanized form of R15E6 does not bind the Tie-2 receptor.

3. The method of claim 1 , wherein administration of the humanized form of R15E6 to the subject enhances VEGF-mediated endothelial cell survival in a dose dependent manner.

4. The method of claim 3 , wherein administration of the humanized form of R15E6 to the subject enhances FGF-mediated endothelial cell survival in a dose dependent manner.

5. The method of claim 1 , wherein administration of the humanized form of R15E6 to the subject activates the Tie-2 receptor in the presence of Ang1 to a greater degree than in the absence of Ang1.

6. A method of enhancing Tie-2 receptor phosphorylation in a subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of a humanized form of R15E6, wherein the humanized form of R15E6 enhances Ang1-induced Tie-2 activation.

7. The method of claim 6 , wherein the humanized form of R15E6 does not bind the Tie-2 receptor.

8. The method of claim 6 , wherein the humanized form of R15E6 enhances Ang1-induced Tie-2 receptor phosphorylation in the presence of VEGF.

9. The method of claim 8 , wherein the humanized form of R15E6 enhances Ang1-induced Tie-2 receptor phosphorylation in the presence of FGF.

10. The method of claim 1 , wherein the humanized form of R15E6 binds to SEQ ID NO: 3.

11. The method of claim 6 , wherein the humanized form of R15E6 binds to SEQ ID NO: 3.