Pharmaceutical composition comprising indole compound
The present invention relates to a pharmaceutical composition comprising a compound of formula (1), (2) or (3) as defined in the specification for the prevention or treatment of diseases associated with oxidative stress, mitochondria dysfunction, hypoxic injury, necrosis and/or ischemic reperfusion injury, and a cosmetic composition comprising an indole compound having an antioxidant effect.
1. A method for the treatment of diseases associated with oxidative stress which is mediated by reactive oxygen species (ROS) or reactive nitrogen species (RNS) selected from the group consisting of cardioplegia and myocardial infarction, comprising
administering a composition which comprises a therapeutically-effective amount of (tetrahydropyran-4-yl)- [2-phenyl-5-(1,1-dioxo-thiomorpholin-4-yl)methyl-1H-indol-7-yl]-amine, or pharmaceutically acceptable salt or isomer thereof as an active ingredient; and a pharmaceutically acceptable carrier to a subject in need thereof.
2. The method of claim 1 , wherein the diseases associated with oxidative stress is myocardial infarction.