Composite containing poly(glycerol sebacate) filler
A filler material of a thermoset resin of a diacid/polyol, such as PGS is provided. The filler useful in forming composites, such as those in which the filler and a resin matrix are of the same material to provide a homogenous polymeric composition. Composites in which at least one of the matrix, the filler or both are PGS are also provided. Methods of forming such filler materials and composites are also disclosed. The composites allow extrusion process to form articles from materials that would not otherwise be capable of being extruded.
1. An article comprising a composite of a matrix formed of a polymer resin and a thermoset filler, the thermoset filler in a thermoset state being mixed with the polymer resin in an uncured state to form the composite, the thermoset filler having a particle size between 0.5 and 1000 microns, wherein the polymer resin, thermoset filler, or both of the polymer resin and thermoset filler comprise polymer of glycerol/sebacic acid (PGS), the thermoset filler being present as about 10% by weight to about 90% by weight of the composite.
2. The article of claim 1 , wherein the polymer resin is in a cured state.
3. The article of claim 1 , wherein the polymer resin has a weight average molecular weight of 5,000-50,000 Da prior to crosslinking.
4. The article of claim 3 , wherein the thermoset filler has a cross-link density of about 0.07 mol/L or greater.
5. The article of claim 1 , wherein the thermoset filler comprises PGS.
6. The article of claim 5 , wherein the polymer resin comprises PGS.
7. The article of claim 6 , wherein the thermoset filler and the polymer resin each have a molar ratio of glycerol to sebacic acid in the range of 0.7:1 to 1.3:1.
8. The article of claim 7 , wherein the thermoset filler and the polymer resin each have the same molar ratio of glycerol to sebacic acid.
9. The article of claim 7 , wherein the molar ratio of glycerol to sebacic acid is 1:1.
10. The article of claim 1 , wherein the composite exhibits antimicrobial activity based on the presence of the PGS.
11. The article of claim 1 , wherein the polymer resin comprises polycaprolactone (PCL), polylactic acid (PLA), polyglycolide (PGA), poly(glycolide-co-lactide) (PLGA), poly(propylene fumarate), poly(ether esters), polydioxanone, poly(ortho esters), polyanhydrides, polycarbonates, co-polymers thereof, blends thereof, urethanes, acrylates, collagen, gelatin, polysaccharides, alginate, glycosaminoglycans, proteoglycans, chitosan, chitin, or agarose.
12. The article of claim 1 further comprising a second filler selected from the group consisting of inorganic salts, calcium phosphate, hydroxyapatite, β-Tricalcium phosphate, titanium dioxide, collagen, gelatin, PCL, PGLA, PGA, PLA and combinations thereof.
13. The article of claim 1 , wherein the composite comprises at least 50% of the thermoset filler, by weight, based on a total weight of the composite.
14. The article of claim 1 , wherein the PGS is doped with an active ingredient.
15. The article of claim 1 , wherein the particle size of the thermoset filler is less than 300 microns.
16. An article comprising a composite of a thermoset filler having a particle size of at least 0.5 microns and less than 250 microns in a cross-linked matrix formed of a polymer resin, the thermoset filler in a thermoset state being mixed with the polymer resin in an uncured state to form the composite, wherein the polymer resin and the thermoset filler both comprise polymer of glycerol/sebacic acid (PGS), the thermoset filler is present from about 40% by weight to about 70% by weight of the composite, the polymer resin has a molecular weight of 5,000-50,000 Da. prior to cross-linking, the thermoset filler has a cross-link density of about 0.07 mol/L or greater, and the thermoset filler and the polymer resin each have a molar ratio of glycerol to sebacic acid in the range of 0.7:1 to 1.3:1.
17. A method of forming an article comprising:
providing a composite comprising a matrix formed of a polymer resin and a thermoset filler having a particle size between 0.5 and 1000 microns, the thermoset filler in a thermoset state being mixed with the polymer resin in an uncured state to form the composite, wherein the polymer resin and the thermoset filler comprise polymer of glycerol/sebacic acid (PGS), the thermoset filler being present as 50% to about 90% by weight of the composite;
forming the composite into a predetermined shape; and
curing the polymer resin.
18. The method of claim 17 , wherein the step of forming comprises extruding.
19. The method of claim 17 , wherein the step of curing is carried out in the absence of a mold at temperatures in the range of 90° C. to 150° C. at less than atmospheric pressure.
20. The article of claim 1 , wherein the article is an adhesion barrier, the article further comprising a textile, the textile reinforcing the composite.
21. The article of claim 1 , wherein the article comprises an adhesion barrier.