Attribute Combination Discovery for Predisposition Determination
A method and system are presented in which a query attribute is used as the basis for accessing stored attribute combinations and their frequencies of occurrence for query-attribute-positive individuals and query-attribute-negative individuals and tabulating, based on frequencies of occurrence, those attribute combinations that are most likely to co-occur with the query attribute.
1 . A computer-based method for generating a recommendation indicating a treatment for a medical condition which the individual is subject to, the computer including a user interface, a processor, a memory, and a display, the computer-based method comprising:
a) receiving at the processor, via the user interface, a query to report on the at least one medical condition with respect to the individual;
b) accessing via the processor an attribute profile associated with the individual, wherein the attribute profile contains pangenetic and non-pangenetic attributes, the pangenetic attributes comprising genetic or epigenetic attributes;
c) accessing via the processor a dataset, stored in the memory, which contains pangenetic attributes, non-pangenetic attributes, treatment regimes, and treatment regime outcomes for a reference set of individuals, the pangenetic attributes comprising genetic or epigenetic attributes;
d) calculating with the processor attribute combinations and a strength of association of the attribute combinations with a successful treatment regime of the reference set of individuals, wherein the attribute combinations contain at least one non-pangenetic attribute;
e) identifying from the attribute combinations of d) and the attributes of the individual a proposed treatment regime for the individual; and
f) generating output for display indicating the proposed treatment regime for the at least one medical condition based on the identified attribute combinations.
2 . The computer based method of claim 1 , wherein the at least one non-pangenetic attribute is smoking related.
3 . The computer based method of claim 1 , wherein the at least one non-pangenetic attribute is alcohol consumption related.
4 . The computer based method of claim 1 , wherein the at least one non-pangenetic attribute is exercise related.
5 . The computer-based method of claim 1 , wherein the medical condition is skin related and the recommendation is a skin treatment regime.
6 . The computer-based method of claim 1 , wherein the medical condition is weight related and the recommendation is a weight loss regime.
7 . The computer-based method of claim 1 , wherein the medical condition is mental health related and the recommendation is a mental health treatment regime.
8 . The computer-based method of claim 2 , wherein the medical condition is skin related and the recommendation is a skin treatment regime.
9 . The computer-based method of claim 2 , wherein the medical condition is weight related and the recommendation is a weight loss regime.
10 . The computer-based method of claim 2 , wherein the medical condition is mental health related and the recommendation is a mental health treatment regime.
11 . The computer-based method of claim 3 , wherein the medical condition is skin related and the recommendation is a skin treatment regime.
12 . The computer-based method of claim 3 , wherein the medical condition is weight related and the recommendation is a weight loss regime.
13 . The computer-based method of claim 3 , wherein the medical condition is mental health related and the recommendation is a mental health treatment regime.
14 . The computer-based method of claim 4 , wherein the medical condition is skin related and the recommendation is a skin treatment regime.
15 . The computer-based method of claim 4 , wherein the medical condition is weight related and the recommendation is a weight loss regime.
16 . The computer-based method of claim 4 , wherein the medical condition is mental health related and the recommendation is a mental health treatment regime.
17 . A computer readable storage medium containing instructions which when executed by a computer result in the execution of a method for generating a recommendation indicating a treatment for a medical condition which the individual is subject to, the method comprising:
a) receiving at the processor, via the user interface, a query to report on the at least one medical condition with respect to the individual;
b) accessing via the processor an attribute profile associated with the individual, wherein the attribute profile contains pangenetic and non-pangenetic attributes, the pangenetic attributes comprising genetic or epigenetic attributes;
c) accessing via the processor a dataset, stored in the memory, which contains pangenetic attributes, non-pangenetic attributes, treatment regimes, and treatment regime outcomes for a reference set of individuals, the pangenetic attributes comprising genetic or epigenetic attributes;
d) calculating with the processor attribute combinations and a strength of association of the attribute combinations with a successful treatment regime of the reference set of individuals, wherein the attribute combinations contain at least one non-pangenetic attribute;
e) identifying from the attribute combinations of d) and the attributes of the individual a proposed treatment regime for the individual; and
f) generating output for display indicating the proposed treatment regime for the at least one medical condition based on the identified attribute combinations.
18 . The computer based method of claim 17 , wherein the at least one non-pangenetic attribute is smoking related.
19 . The computer based method of claim 17 , wherein the at least one non-pangenetic attribute is alcohol consumption related.
20 . The computer based method of claim 17 , wherein the at least one non-pangenetic attribute is exercise related.