N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides
View Patent ↗The invention relates to (among other things) N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides and compositions comprising the same. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.
1. A compound of Formula I-C:
wherein:
Ar is benzyl, phenyl, naphthyl, biphenyl, or phenanthrenyl;
R 1 is methyl, ethyl, n-butyl, i-butyl, or t-butyl;
X 1 is a single bond, —O—, —S—, —NH—, or —NHC(O)—; and
POLY 1 is a poly(ethylene oxide) oligomer having from 1 to 15 monomers;
and pharmaceutically acceptable salts thereof.
2. The compound of claim 1 , according to Formula I-C(R):
and pharmaceutically acceptable salts thereof.
3. The compound of claim 1 , according to Formula I-C(S):
and pharmaceutically acceptable salts thereof.
4. The compound of claim 1 , wherein POLY 1 is end-capped with hydroxy, methoxy, ethoxy, or benzyloxy.
5. The compound of claim 1 , wherein POLY 1 is end-capped with methoxy.
6. The compound of claim 1 , wherein X 1 is —NHC(O)—.
7. The compound of claim 1 , wherein Ar is phenyl.
8. The compound of claim 1 , wherein R 1 is methyl.
9. The compound of claim 1 , according to formula:
wherein n is 1, 2, 3, 4, 5, 6, 7, 8, or 9; and pharmaceutically acceptable salts thereof.
10. A composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient.