Methods for electrical neuromodulation of the heart
The present disclosure provides for a method for treating a patient in which a catheter having an electrode array is moved through the pulmonary trunk of the patient towards a branch point that helps to define the beginning of a left pulmonary artery and a right pulmonary artery of the heart. The electrode array is positioned in the right pulmonary artery where the electrodes contact a posterior surface, a superior surface and/or an inferior surface of the right pulmonary artery. The one or more electrodes can be positioned to contact the posterior surface, the superior surface and/or the inferior surface of the right pulmonary artery at a position superior to the branch point. The electrode array can also be positioned in the right pulmonary artery no more than three times the diameter of the pulmonary trunk to the right of the branch point.
1. A method of modulating an autonomic cardiopulmonary nerve to treat acute heart failure, the method comprising:
positioning a distal portion of a catheter comprising an electrode array in a subject, the electrode array comprising electrodes on only one side of a plurality of sides of the electrode array, the subject comprising:
a pulmonary trunk;
a right lateral plane passing along a right luminal surface of the pulmonary trunk;
a left lateral plane parallel to the right lateral plane, the left lateral plane passing along a left luminal surface of the pulmonary trunk;
a branch point between the right lateral plane and the left lateral plane, the pulmonary trunk having a diameter taken across a plane perpendicular to the left lateral plane and the right lateral plane;
a right pulmonary artery; and
a left pulmonary artery, the branch point at least partially defining a beginning of the left pulmonary artery and the right pulmonary artery;
positioning the electrode array in the right pulmonary artery to the right of the left lateral plane;
contacting the electrode array on a superior surface and an anterior surface of the right pulmonary artery or on a superior surface of the right pulmonary artery;
providing electrical current to at least one electrode of the electrode array, the electrical current increasing cardiac contractility to treat the acute heart failure;
measuring a value of a cardiac parameter in response to the electrical current,
wherein the cardiac parameter comprises at least one of a pressure parameter, an acoustic parameter, an acceleration parameter, and an electrical parameter; and
moving the electrode array, wherein moving the electrode array comprises changing which electrodes of the electrode array are used to electrically move the electrode array in response to the value of the cardiac parameter.
2. The method of claim 1 ,
wherein moving the electrode array comprises
changing a physical position of the electrode array to physically move the electrode array in response to the value of the cardiac parameter.
3. The method of claim 1 , wherein contacting the electrode array comprises contacting the electrode array superior to the branch point.
4. The method of claim 1 , wherein positioning the electrode array comprises positioning the electrode array to the right of the branch point by no more than three times the diameter of the pulmonary trunk.
5. The method of claim 1 , wherein the right pulmonary artery comprises a second branch point that divides the right pulmonary artery into at least two additional arteries, and wherein positioning the electrode array comprises positioning the electrode array between the branch point and the second branch point.
6. The method of claim 1 , wherein the cardiac parameter comprises a pressure parameter.
7. A method of modulating an autonomic cardiopulmonary nerve, the method comprising:
positioning a distal portion of a catheter comprising an electrode array in a subject, the electrode array comprising electrodes on only one side of a plurality of sides of the electrode array, the subject comprising:
a pulmonary trunk;
a left lateral plane passing along a left luminal surface of the pulmonary trunk; and
a right pulmonary artery;
positioning the electrode array in the right pulmonary artery to the right of the left lateral plane;
contacting the electrode array on a superior surface of the right pulmonary artery;
providing electrical current to at least one electrode of the electrode array, the electrical current increasing cardiac contractility;
measuring a value of a cardiac parameter in response to the electrical current; and
changing which electrodes of the electrode array are used to electrically move the electrode array in response to the value of the cardiac parameter.
8. The method of claim 7 , comprising contacting the electrode array on the superior surface and an anterior surface of the right pulmonary artery.
9. The method of claim 7 , wherein the cardiac parameter comprises at least one of a pressure parameter, an acoustic parameter, an acceleration parameter, and an electrical parameter.
10. The method of claim 7 , further comprising changing a physical position of the electrode array to physically move the electrode array in response to the value of the cardiac parameter.
11. The method of claim 7 , further comprising:
contacting the electrode array on the superior surface of the right pulmonary artery and an anterior surface of the right pulmonary artery;
wherein the cardiac parameter comprises at least one of a pressure parameter, an acoustic parameter, an acceleration parameter, and an electrical parameter.
12. The method of claim 7 , wherein the cardiac parameter comprises a pressure parameter.
13. A method of modulating an autonomic cardiopulmonary nerve, the method comprising:
contacting an electrode array on a superior surface of a right pulmonary artery, the electrode array comprising electrodes on only one side of a plurality of sides of the electrode array;
providing electrical current to at least one electrode of the electrode array to increase cardiac contractility;
measuring a value of a cardiac parameter in response to the electrical current; and
changing which electrodes of the electrode array are used to electrically move the electrode array in response to the value of the cardiac parameter.
14. The method of claim 13 , comprising contacting the electrode array on the superior surface and an anterior surface of the right pulmonary artery.
15. The method of claim 13 , wherein the cardiac parameter comprises at least one of a pressure parameter, an acoustic parameter, an acceleration parameter, and an electrical parameter.
16. The method of claim 13 , further comprising changing a physical position of the electrode array to physically move the electrode array in response to the value of the cardiac parameter.
17. The method of claim 13 , wherein contacting the electrode array comprises contacting the electrode array superior to a branch point between the right pulmonary artery and a left pulmonary artery.
18. The method of claim 13 , further comprising:
contacting the electrode array on the superior surface of the right pulmonary artery and an anterior surface of the right pulmonary artery,
wherein the cardiac parameter comprises at least one of a pressure parameter, an acoustic parameter, an acceleration parameter, and an electrical parameter.
19. The method of claim 13 , wherein the cardiac parameter comprises a pressure parameter.