IP Library Granted Patent US 9,918,670
Granted Patent B2
US 9,918,670 · App. 15/449,405 · Granted Mar 20, 2018

Detecting seizures based on heartbeat data

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Quick Facts
Patent No.
US 9,918,670
App. No.
15/449,405
Granted
Mar 20, 2018
Kind
B2
Abstract

A method includes receiving heartbeat data of a patient and receiving activity data of the patient. The activity data includes one or more activity values that are related to an activity level of the patient and that are measured independently of the heartbeat data. The method further includes determining a value of a weighting factor based on the activity data. The method also includes determining modified heartbeat data by applying the weighting factor to at least a portion of the heartbeat data. The method also includes detecting a seizure event based on the modified heartbeat data.

Claims (37)

1. A method comprising:

receiving heartbeat data of a patient;

receiving accelerometer data of the patient;

determining, using the accelerometer data, that the patient is transitioning from a sleep state to an awake state;

decreasing a weighting factor based on the transition;

determining modified heartbeat data by applying the weighting factor to at least a portion of the heartbeat data; and

detecting a seizure event based on the modified heartbeat data.

2. The method of claim 1 , wherein determining the modified heartbeat data includes determining a background (BG) heart rate based on a previously-determined BG heart rate, a most recent R-R interval, and the weighting factor.

3. The method of claim 2 , wherein the BG heart rate is determined as a sum of a first value and a second value, wherein the first value is the weighting factor times the previously-determined BG heart rate and the second value is one minus the weighting factor times the most recent R-R interval.

4. The method of claim 2 , wherein determining the modified heartbeat data further includes determining a foreground (FG) heart rate based on one or more R-R intervals of the heartbeat data.

5. The method of claim 4 , wherein detecting the seizure event comprises comparing a ratio of the FG heart rate and the BG heart rate to a seizure detection threshold.

6. The method of claim 1 , wherein the heartbeat data of the patient includes electrocardiogram data.

7. The method of claim 6 , wherein the electrocardiogram data indicates a timing related to a plurality of R-waves.

8. The method of claim 1 , further comprising causing, in response to the detection of the seizure event, initiation of at least one of a stimulation to tissue of the patient, a reporting of the occurrence of the seizure event, or a recording of the seizure event.

9. A medical device comprising:

a first interface to receive heartbeat data of a patient;

a second interface to receive acceleration data of the patient; and

a processor configured to:

determine, using the accelerometer data, that the patient is transitioning from a sleep state to an awake state;

decrease a weighting factor based on the transition;

determine modified heartbeat data by applying the weighting factor to at least a portion of the heartbeat data; and

detect a seizure event based on the modified heartbeat data.

10. The medical device of claim 9 , wherein determining the modified heartbeat data includes determining a background (BG) heart rate based on a previously-determined BG heart rate, a most recent R-R interval, and the weighting factor.

11. The medical device of claim 10 , wherein the BG heart rate is determined as a sum of a first value and a second value, wherein the first value is the weighting factor times the previously-determined BG heart rate and the second value is one minus the weighting factor times the most recent R-R interval.

12. The medical device of claim 10 , wherein determining the modified heartbeat data further includes determining a foreground (FG) heart rate based on one or more R-R intervals of the heartbeat data, wherein the seizure event is detected by comparing a ratio of the FG heart rate and the BG heart rate to a seizure detection threshold.

13. The medical device of claim 9 , wherein the processor, in response to the detection of the seizure event, provides a signal to at least one of stimulation device disposed to provide stimulation to tissue of the patient, a signal indicating the occurrence of the seizure event, and a signal initiating the recording of the seizure event.

14. A non-transitory computer-readable medium storing instructions that are executable by a processor to cause the processor to perform operations including:

receiving heartbeat data of a patient;

receiving accelerometer data of the patient;

determining, using the accelerometer data, that the patient is transitioning from a sleep state to an awake state;

decreasing a weighting factor based on the transition;

determining modified heartbeat data by applying the weighting factor to at least a portion of the heartbeat data; and

detecting a seizure event based on the modified heartbeat data.

15. The non-transitory computer-readable medium of claim 14 , wherein determining the modified heartbeat data includes determining a background (BG) heart rate based on a previously-determined BG heart rate, a most recent R-R interval, and the weighting factor.

16. The non-transitory computer-readable medium of claim 15 , wherein the BG heart rate is determined as a sum of a first value and a second value, wherein the first value is the weighting factor times the previously-determined BG heart rate and the second value is one minus the weighting factor times the most recent R-R interval.

17. The non-transitory computer-readable medium of claim 15 , wherein determining the modified heartbeat data further includes determining a foreground (FG) heart rate based on one or more R-R intervals of the heartbeat data, wherein the seizure event is detected by comparing a ratio of the FG heart rate and the BG heart rate to a seizure detection threshold.

18. The non-transitory computer-readable medium of claim 14 , wherein the processor, in response to the detection of the seizure event, provides a signal to at least one of stimulation device disposed to provide stimulation to tissue of the patient, a signal indicating the occurrence of the seizure event, and a signal initiating the recording of the seizure event.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Sep 20, 2021
From: ACF FINCO I LP
To: LIVANOVA USA, INC.
Reel/Frame 057552/0378 →
SECURITY INTEREST Recorded Aug 16, 2021
From: LIVANOVA USA, INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 057188/0001 →
RELEASE OF SECURITY INTEREST Recorded Aug 16, 2021
From: ARES CAPITAL CORPORATION, AS AGENT FOR THE LENDERS
To: LIVANOVA USA, INC.
Reel/Frame 057189/0001 →
PATENT SECURITY AGREEMENT Recorded Dec 30, 2020
From: LIVANOVA USA, INC.
To: ACF FINCO I LP, AS COLLATERAL AGENT
Reel/Frame 054881/0784 →
CHANGE OF NAME Recorded Jun 29, 2020
From: CYBERONICS, INC.
To: LIVANOVA USA, INC.
Reel/Frame 053306/0229 →
PATENT SECURITY AGREEMENT Recorded Jun 17, 2020
From: LIVANOVA USA, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 053673/0675 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 2, 2018
From: SABESAN, SHIVKUMAR
To: CYBERONICS, INC.
Reel/Frame 044819/0150 →