Bioerodible Wraps and Uses Therefor
A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
1 .- 222 . (canceled)
223 . A tubular tissue graft device comprising:
a living tubular tissue harvested from a patient having a wall defining a lumen, the lumen extending from a first end of the living tubular tissue to a second end of the living tubular tissue, the wall having an exterior surface; and
an electrospun fiber matrix deposition comprising a polymer, the electrospun fiber matrix deposition surrounding the exterior surface of the living tubular tissue,
wherein the electrospun fiber matrix deposition is configured to biodegrade over a period of from about two months to about one year.
224 . The tubular tissue graft device according to claim 223 , wherein the electrospun fiber matrix deposition is configured to biodegrade over a period of from about two months to about six months.
225 . The tubular tissue graft device according to claim 223 , wherein the electrospun fiber matrix deposition comprises a non-linear biodegradation rate.
226 . The tubular tissue graft device according to claim 223 , wherein the electrospun fiber matrix deposition surrounds the exterior surface of the living tubular tissue from the first end to the second end of the living tubular tissue.
227 . The tubular tissue graft device according to claim 223 , wherein the electrospun fiber matrix deposition comprises a thickness that varies along at least a portion of a length of the tubular tissue graft device.
228 . The tubular tissue graft device according to claim 223 , wherein the living tubular tissue comprises a vein.
229 . The tubular tissue graft device according to claim 223 , wherein the living tubular tissue comprises a saphenous vein.
230 . The tubular tissue graft device according to claim 223 , wherein the living tubular tissue comprises tissue selected from the group consisting of: vein; artery; urethra; intestine; esophagus; ureter; trachea; bronchi; fallopian tube; and any combination thereof.
231 . The tubular tissue graft device according to claim 223 , further comprising a scaffold disposed relative to the electrospun fiber matrix deposition and surrounding the exterior surface of the living tubular tissue.
232 . The tubular tissue graft device according to claim 231 , wherein the scaffold surrounds the exterior surface of the living tubular tissue from the first end to the second end of the living tubular tissue.
233 . The tubular tissue graft device according to claim 231 , wherein the exterior surface of the living tubular tissue defines a circumference, and wherein the scaffold surrounds the circumference of the living tubular tissue.
234 . The tubular tissue graft device according to claim 231 , wherein the scaffold surrounds the electrospun fiber matrix deposition.
235 . The tubular tissue graft device according to claim 231 , wherein the scaffold is positioned between the living tubular tissue and the electrospun fiber matrix deposition.
236 . The tubular tissue graft device according to claim 231 , wherein the scaffold has at least one of a mesh structure, a coil structure, a braided structure, or a knitted structure.
237 . The tubular tissue graft device according to claim 231 , wherein the scaffold has a stent-like construction.
238 . The tubular tissue graft device according to claim 231 , wherein the scaffold comprises a first material and the electrospun fiber matrix deposition comprises a second material.
239 . The tubular tissue graft device according to claim 231 , wherein the scaffold comprises a biodegradable material.
240 . The tubular tissue graft device according to claim 231 , wherein the scaffold is configured to provide a radial supporting force to the living tubular tissue, the radial supporting force having a magnitude capable of changing over time.
241 . The tubular tissue graft device according to claim 231 , wherein the scaffold comprises at least one of a resiliently biased portion, a plastically deformable portion, and a combination thereof.
242 . The tubular tissue graft device according to claim 231 , wherein the scaffold is configured to provide an anchoring mechanism for the tubular tissue graft device.