Antibacterial cyclopenta[C]pyrrole substituted 3,4-Dihydro-1H-[1,8]naphthyridinones

Inventors: Jerôme Emile Georges Guillemont (Ande, FR); David Francis Alain Lançois (Louviers, FR); Magali Madeleine Simone Motte (Louviers, FR); Anil Koul (Edegem, BE); Wendy Mia Albert Balemans (Kalmthout, BE); Eric Pierre Alexandre Arnoult (Le Vaudreuil, FR)

Assignee: Janssen Sciences Ireland UC

C07D471/04 C07D519/00

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Quick Facts

Patent No.: US 9,884,864
App. No.: 15/454,703
Granted: Feb 6, 2018
Kind: B2

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Abstract

The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.

Claims (4)

1. A compound selected from the group consisting of:

and pharmaceutically acceptable salts thereof.

2. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and an effective amount of a compound selected from the group consisting of:

and pharmaceutically acceptable salts thereof.

Assignments (11)

CHANGE OF NAME Recorded Mar 6, 2019

From: JANSSEN SCIENCES IRELAND UC

To: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY

Reel/Frame 048523/0408 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 7, 2018

From: KOUL, ANIL

To: JANSSEN PHARMACEUTICA NV

Reel/Frame 046576/0468 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 7, 2018

From: BALEMANS, WENDY MIA ALBERT