PREVENTION AND TREATMENT OF THROMBOSIS IN MEDICALLY ILL PATIENTS
Provided herein are methods for preventing and treating thrombosis in medically ill patients by administering to the patient a therapeutically effective amount of betrixaban.
1 . A method for the prevention or treatment of thrombosis in a medically ill patient, comprising administering to the patient a therapeutically effective amount of betrixaban.
2 . The method of claim 1 , wherein the patient is at risk of developing a venous thromboembolic disease.
3 . The method of claim 1 , wherein the patient suffers from one or more of (a) acutely decompensated heart failure, (b) acute respiratory failure, (c) acute infection without septic shock, (d) an acute rheumatic disorder or (e) cancer.
4 . The method of claim 1 , wherein the patient suffers from decreased mobility.
5 . The method of claim 1 , wherein betrixaban is administered to the patient once daily or twice daily.
6 . The method of claim 1 , wherein betrixaban is in the form of a pharmaceutically acceptable salt.
7 . The method of claim 6 , wherein the pharmaceutically acceptable salt of betrixaban is a maleate salt.
8 . The method of claim 1 , wherein betrixaban is administered in an amount of about 20 mg to about 80 mg per day.
9 . The method of claim 1 , wherein betrixaban is administered in an amount of about 40 mg to about 80 mg per day.
10 . The method of claim 1 , wherein betrixaban is administered with food.
11 . The method of claim 1 , wherein the patient receives about 160 mg of betrixaban prior to the administration.
12 . The method of claim 1 , wherein the thrombosis is venous thrombosis.