METHODS FOR REDUCING OR PREVENTING TRANSPLANT REJECTION IN THE EYE AND INTRAOCULAR IMPLANTS FOR USE THEREFOR
Methods for reducing or preventing transplant rejection in the eye of an individual are described; comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
1 . A solid bioerodible implant for reducing or preventing transplant rejection in an eye of an individual, the implant comprising about 50% by weight of dexamethasone, about 15% by weight of hydroxypropyl methylcellulose (HPMC), and about 35% by weight of Resomer RG 502H PLGA.
2 . A solid bioerodible implant for reducing or preventing transplant rejection in an eye of an individual, the implant comprising about 60% by weight of dexamethasone, about 30% by weight of Resomer RG 502H PLGA, and about 10% by weight of Resomer RG 502 PLGA.
3 . A method for reducing or preventing transplant rejection in an eye of an individual, the method comprising:
a) performing an ocular transplant procedure on an eye of an individual; and
b) implanting in the eye a solid bioerodible implant according to claim 1 , thereby reducing or preventing transplant rejection.
4 . A method for reducing or preventing transplant rejection in an eye of an individual, the method comprising:
a) performing an ocular transplant procedure on an eye of an individual; and
b) implanting in the eye a solid bioerodible implant according to claim 2 , thereby reducing or preventing transplant rejection.