Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, nutraceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor. The system can utilize a pump, pressurized reservoir, a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with porous membranes or micro-fabricated structures.
1. A device for transdermal administration of an active substance, the device comprising:
a pressurized reservoir;
a solution comprising the active substance and a solvent disposed in the pressurized reservoir;
a porous skin interface adapted to receive the solution from the reservoir and to transfer the active substance to the skin; and
an evaporation channel defining a flow path for flow of evaporated solvent from the porous skin interface therethrough.
2. The device of claim 1 , further comprising: a solvent recovery element communicating with the skin interface and adapted to receive the evaporated solvent, wherein the solvent recovery element comprises a desiccant, absorbent material, or hydrophilic material.
3. The device of claim 1 , further comprising: a solvent recovery element communicating with the skin interface and adapted to receive the evaporated solvent and a vapor permeable material disposed between the skin interface and the solvent recovery element.
4. The device of claim 1 , further comprising: a piston disposed in the pressurized reservoir in contact with the solution.
5. The device of claim 1 , further comprising: a valve controlling flow of the solution from the pressurized reservoir to the skin interface.
6. The device of claim 5 , further comprising: a programmable control unit adapted to control the valve.
7. The device of claim 1 , wherein the porous skin interface comprises adhesive.
8. The device of claim 1 , further comprising: a housing into which the pressurized reservoir, porous skin interface, and evaporation channel are incorporated.
9. The device of claim 1 , further comprising: an administration reservoir adapted to receive the solution from the pressurized reservoir and to communicate with the porous skin interface.
10. The device of claim 1 , wherein the active substance comprises an opiate, and wherein the opiate comprises fentanyl, codeine, dihydrocodeine, hydrocodone, hydromorphone, Sufentanil, Nalbuphine, Buprenorphine, Hydromorphone or other opiate derivative.
11. The device of claim 1 , further comprising: a display.
12. The device of claim 1 , wherein the device includes a disposable portion and a reusable portion, wherein the disposable portion and the reusable portion are adapted to be coupled together.
13. The device of claim 12 , wherein the disposable portion includes the pressurized reservoir, the solution of the active substance and the solvent disposed in the pressurized reservoir, the porous skin interface, and the evaporation channel.
14. The device of claim 12 , wherein the reusable portion includes a programmable control unit and a power source.
15. A method for delivering an active substance to a human comprising: delivering the active substance dissolved in a solvent from a pressurized reservoir of a transdermal drug delivery device to a porous skin-interface membrane of the transdermal drug delivery device coupled to a skin of the human; absorbing the active substance from the porous skin-interface membrane transdermally into the human; and moving evaporated solvent from the skin-interface membrane through an evaporation channel of the transdermal drug delivery device.
16. The method of claim 15 , further comprising: repeating the delivering, absorbing and moving steps to modulate and control dosing to create a plurality of active substance blood plasma concentration peaks and troughs in the human.
17. The method of claim 15 , wherein the active substance is an opiate, and wherein the opiate comprises fentanyl, codeine, dihydrocodeine, hydrocodone, hydromorphone, Sufentanil, Nalbuphine, Buprenorphine, Hydromorphone or other opiate derivative.
18. The method of claim 15 , wherein delivering the active substance dissolved in the solvent to the skin-interface membrane of the transdermal drug delivery device coupled to the human includes delivering the active substance at a time, rate, sequence and/or cycle that is synchronized with a biological rhythm of the human.
19. The method of claim 15 , wherein the method further includes moving solvent from the skin-interface membrane into a solvent removal element, and wherein the solvent removal element comprises a desiccant, absorbent material, or hydrophilic material.
20. The method of claim 15 , wherein the active substance is an opiate, and wherein the opiate is for a purpose of chronic pain management.
21. The method of claim 15 , wherein the active substance is an opiate, and wherein the opiate is for a purpose of acute pain management.
22. The method of claim 15 whereby permeation through the skin is assisted using one or more from the group comprising: micro-fabricated structures, heat, sonophoresis, and a chemical permeation enhancer.
23. The method of claim 15 , wherein the delivery step comprises delivering a first dosage of active substance to the human to raise the human's blood plasma concentration of active substance from a first level to a second level higher than the first level while the human is asleep.
24. The method of claim 23 , wherein delivering the first dosage of active substance to the human is at a time around 3 a.m. to 8 a.m.
25. The method of claim 23 , wherein the second level of the blood plasma concentration is about 2-8 ng/ml.
26. The method of claim 23 , wherein the delivery step further comprises reducing or stopping delivery of active substance to the human to reduce the human's blood plasma concentration of active substance from the second level to a third level lower than the second level, then delivering a second dosage of active substance to the human to increase the human's blood plasma concentration of active substance from the third level to a fourth level higher than the third level.
27. The method of claim 26 , wherein the second dosage of active substance to the human is at a time around 5 p.m. to about 3 a.m.
28. The method of claim 26 , wherein the third level of the blood plasma concentration is about 1-3 ng/ml.
29. The method of claim 26 , wherein the third level of the blood plasma concentration is around 8 a.m. to around 5 p.m.
30. The method of claim 26 , wherein the fourth level of the blood plasma concentration is about 2-5 ng/ml.
31. The method of claim 26 , wherein the active substance is fentanyl.
32. The method of claim 15 , further comprising: removing the transdermal drug delivery device after contacting the skin for greater than 24 hours.
33. The method of claim 15 , wherein delivering the active substance dissolved in the solvent to the skin-interface membrane of the transdermal drug delivery device coupled to the skin of the human is performed immediately before the human wakes up.
34. The method of claim 15 , wherein the transdermal drug delivery device includes a reservoir with the active substance dissolved in the solvent and further comprising: moving a portion of the active substance dissolved in the solvent from the reservoir to the skin-interface membrane.