IP Library Granted Patent US 11,054,432
Granted Patent B2
US 11,054,432 · App. 15/461,081 · Granted Jul 6, 2021

Systems and methods for multi-purpose analysis

Inventors: Elizabeth A. Holmes (Palo Alto, CA); Joy Roy (San Jose, CA); Peter Kardassakis (Mountain View, CA)
Assignee: Labrador Diagnostics LLC
G01N35/02C12Q1/00C12Q1/02C12Q1/28C12Q1/68G01N30/02G01N33/48G01N33/559G01N33/566G01N33/86G01N35/00G01N35/0092G01N2035/00326G01N2035/00495
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Quick Facts
Patent No.
US 11,054,432
App. No.
15/461,081
Granted
Jul 6, 2021
Kind
B2
Abstract

Systems and methods are provided for sample processing. The system, in one configuration, includes a sample processing apparatus for use with a biological sample and/or a reagent, a housing and a touchscreen display mounted to the housing. The system, in one configuration, contains a cartridge insertion location; at least one optical detector; a control unit having a processor that is programmed to execute computer-readable commands; and a sample handling system.

Claims (37)

1. A sample processing apparatus to receive a cartridge and for use with a biological sample and/or a reagent, the apparatus comprising:

a housing;

a touchscreen display mounted to the housing; and

a control unit having a processor that is programmed to execute computer-readable commands;

said housing containing the following components:

a tray defining a cartridge insertion location;

at least one optical detector; and

a sample handling system having a common support and at least a first pipette body and at least a second pipette body, each pipette body having a chassis and each mounted on the common support structure, wherein at least one of the at least first pipette body and the at least second pipette body is independently movable and independently controllable in relation to the other, and wherein the sample handling system transfers the biological sample or the reagent from or to one or more locations within said housing, wherein the at least first pipette body or the at least second pipette body of the sample handling system is positionable to individually access each of the at least one detector and the cartridge insertion location; wherein each of the at least a first pipette body and the at least a second pipette body comprises: a pipette nozzle, a motor, a valve, a lead screw, and a piston;

wherein the control unit is operably linked to communicate with the sample handling system, the touchscreen, and the at least one optical detector.

2. The apparatus of claim 1 , wherein the at least a first pipette body is sized to aspirate a fluid having a volume no more than 100 uL.

3. The apparatus of claim 1 , further comprising a tip, wherein the pipette nozzle of the at least first pipette body is configured to connect with the tip that is removable from the pipette nozzle of the at least first pipette body, and wherein the tip is configured to hold a sample having a volume no more than 100 μL.

4. The apparatus of claim 1 wherein one of the at least first pipette body or the at least second pipette body has a height, width, and length each of which dimension does not exceed 20 cm.

5. The apparatus of claim 4 wherein one of the at least first pipette body or the at least second pipette body has a height which does not exceed 7 cm.

6. The apparatus of claim 4 , wherein the at least first pipette body comprises a positive displacement pipette and the at least second pipette body comprises an air displacement pipette.

7. The apparatus of claim 1 wherein the tray comprises a movable tray.

8. A sample processing apparatus to receive a cartridge and for use with a biological sample and/or a reagent, the apparatus comprising:

a housing;

a touchscreen display mounted to the housing; and

a control unit having a processor that is programmed to execute computer-readable commands;

said housing containing the following components:

an opening in the housing;

a tray defining a cartridge insertion location;

at least one optical detector; and

a sample handling system having a common support and at least a first pipette body and at least a second pipette body, each pipette body having a chassis and each mounted on the common support structure, wherein at least one of the at least first pipette body and the at least second pipette body is independently movable and independently controllable in relation to the other, and wherein the sample handling system transfers the biological sample or the reagent from or to one or more locations within said housing, wherein the at least first pipette body or the at least second pipette body of the sample handling system is positionable to individually access each of the at least one detector and the cartridge insertion location;

wherein each of the at least a first pipette body and the at least a second pipette body comprises: a pipette nozzle, a motor, a valve, a lead screw, and a piston;

wherein the control unit is operably linked to communicate with the sample handling system, the touchscreen, and the at least one optical detector.

9. A sample processing apparatus to receive a cartridge and for use with a biological sample and/or a reagent, the apparatus comprising:

a housing;

a touchscreen display mounted to the housing;

a camera mounted to the housing; and

a control unit having a processor that is programmed to execute computer-readable commands;

said housing containing the following components:

a tray defining a cartridge insertion location;

at least one optical detector; and

a sample handling system having a common support and at least a first pipette body and at least a second pipette body, each pipette body having a chassis and each mounted on the common support structure, wherein at least one of the at least first pipette body and the at least second pipette body is independently movable and independently controllable in relation to the other, and wherein the sample handling system transfers the biological sample or the reagent from or to one or more locations within said housing, wherein the at least first pipette body or the at least second pipette body of the sample handling system is positionable to individually access each of the at least one detector and the cartridge insertion location;

wherein each of the at least a first pipette body and the at least a second pipette body comprises: a pipette nozzle, a motor, a valve, a lead screw, and a piston;

wherein the control unit is operably linked to communicate with the sample handling system, the touchscreen, and the at least one optical detector.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 17, 2021
From: KARDASSAKIS, PETER; ROY, JOY
To: THERANOS, INC.
Reel/Frame 055623/0807 →
CHANGE OF NAME Recorded Apr 15, 2020
From: THERANOS IP COMPANY, LLC
To: LABRADOR DIAGNOSTICS LLC
Reel/Frame 052410/0432 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2018
From: THERANOS, INC.
To: THERANOS IP COMPANY, LLC
Reel/Frame 045075/0310 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2017
From: THERANOS INC.
To: THERANOS IP COMPANY, LLC
Reel/Frame 044838/0909 →
SECURITY INTEREST Recorded Dec 12, 2017
From: THERANOS IP COMPANY, LLC
To: FORTRESS CREDIT CORP.
Reel/Frame 044839/0568 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 28, 2017
From: HOLMES, ELIZABETH; BALWANI, SUNNY
To: THERANOS, INC.
Reel/Frame 042107/0998 →
Continuity (3)
Continuation 13244949 · Sep 26, 2011
Continuation In Part PCTUS2011053188 · Sep 25, 2011
Related Publication 20170283845A1 · Oct 5, 2017