Anti-cancer agents
An anti-cancer agent having the formula: wherein Ph is a phenyl group and Ar is an aromatic group independently selected from the group consisting of phenyl, 2-bromophenyl, 4-bromophenyl, 2-chlorophenyl, 2,4, dichlorophenyl, 4-chlorophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2 methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, and 3-nitrophenyl; or a pharmaceutically acceptable salt thereof.
1. An anti-cancer agent, comprising a dispiropyrrolidine tethered piperidone compound having the formula:
wherein Ph is a phenyl group and Ar is an aromatic group independently selected from the group consisting of phenyl, 2-bromophenyl, 4-bromophenyl, 2-chlorophenyl, 2,4, dichlorophenyl, 4-chlorophenyl, 2-methylphenyl, 3-methyl phenyl, 4-methylphenyl, 2 methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, and 3-nitrophenyl; or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition, comprising the anti-cancer agent according to claim 1 and a pharmaceutically acceptable carrier, excipient or diluent.
3. A method for treating cancer, comprising the step of administering to a patient in need thereof a therapeutically effective amount of the anti-cancer agent for a cancer selected from the group consisting of colon, breast, prostate, and blood cancer according to claim 1 .
4. The method for treating cancer according to claim 3 , wherein the effective amount includes a dose amount that provides an in vivo concentration of about 10 μm to about 100 μm.
5. A method of making the anti-cancer agent of claim 1 , comprising:
providing a reaction mixture including indoline-2,3-dione, L-phenylalanine, and an N-arylidene piperidone derivative compound; and
refluxing the reaction mixture in an organic solvent to yield the dispiropyrrolidine tethered piperidone of claim 1 .
6. The method of making the anti-cancer agent according to claim 5 , wherein a molar ratio of indoline-2, 3-dione:L-phenylalanine:N-arylidene piperidone derivative compound is 2:2:1.
7. The method of making the anti-cancer agent according to claim 5 , wherein the reaction mixture is refluxed for about two hours.
8. The method of making the anti-cancer agent according to claim 5 , wherein the organic solvent is methanol.
9. The method of making the anti-cancer agent according to claim 5 , wherein the N-arylidene piperidone derivative compound includes (3E,5E)-3,5-bis(4-arylbenzylidene)piperidin-4-one.